Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy:demographic,virological,and clinical features  

作　　者：Nicola Coppola Loredana Alessio Luciano Gualdieri Mariantonietta Pisaturo Caterina Sagnelli Carmine Minichini Giovanni Di Caprio Mario Starace Lorenzo Onorato Giuseppe Signoriello Margherita Macera Italo Francesco Angelillo Giuseppe Pasquale Evangelista Sagnelli 

机构地区：[1]Department of Mental Health and Public Medicine,Section of Infectious Diseases,Second University of Naples,Via L.Armanni 5,80133 Naples,Italy [2]Medical Center,Social center“ex Canapificio”,Caserta,Italy [3]Medical Center,Center for the wardship of the immigrants,Naples,Italy [4]Medical Center,Welcome center‘La tenda di Abramo’,Caserta,Italy [5]Infectious Diseases Unit,AORN Sant’Anna e San Sebastiano,Caserta,Italy [6]Department of Clinical and Experimental Medicine and Surgery,Second University of Naples,Naples,Italy [7]Medical center,Center of missionary nuns of carithy,Naples,Italy [8]Department of Mental Health and Public Medicine,Section of Statistic,Second University of Naples,Naples,Italy [9]Department of Experimental Medicine,Second University of Naples,Naples,Italy

出　　处：《Infectious Diseases of Poverty》2017年第1期283-291,共9页贫困所致传染病（英文）

基　　金：This study was supported in part by a grant from Gilead Sciences S.r.l.‘L’infezione da HBV nelle popolazioni speciali(donne in gravidanza,popolazioni immigrate,popolazioni in etàpediatrica):progetti di awareness ed accesso alla diagnosi’Fellowship Program 2011 and 2013;by a grant from 2014 goSHAPE program。

摘　　要：Background:The data on hepatitis b virus(HBV)infection in immigrants population are scanty.The porpoise of this study was to define the demographic,virological,and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples,Italy.Methods:A screening for HBV infection was offered to 1,331 immigrants,of whom 1,212(91%)(831 undocumented immigrants and 381 refugees)accepted and were screened for hepatitis B surface antigen(HBsAg)and anti-hepatitis B core antibody(HBc).Those found to be HBsAg positive were further investigated at third-level infectious disease units.Results:Of the 1,212 immigrants screened,116(9.6%)were HBsAg positive,490(40.4%)were HBsAg negative/anti-HBc positive,and 606(50%)were seronegative for both.Moreover,21(1.7%)were anti-human immunodeficiency virus positive and 45(3.7%)were anti-hepatitis C virus positive.The logistic regression analysis showed that male sex(OR:1.79;95%CI:1.28-2.51),Sub-Saharan African origin(OR:6.18;95%CI:3.37-11.36),low level of schooling(OR:0.96;95%CI:0.94-0.99),and minor parenteral risks for acquiring HBV infection(acupuncture,tattoo,piercing,or tribal practices,OR:1.54;95%CI:1.1-2.16)were independently associated with ongoing or past HBV infection.Of the 116 HBsAg-positive immigrants,90(77.6%)completed their diagnostic itinerary at a third-level infectious disease unit:29(32.2%)were asymptomatic non-viremic HBsAg carriers,43(47.8%)were asymptomatic viremic carriers,14(15.6%)had chronic hepatitis,and four(4.4%)had liver cirrhosis,with superimposed hepatocellular carcinoma in two.Conclusions:The data illustrate the demographic,clinical and virological characteristics of HBV infection in immigrants in Italy and indicate the need for Italian healthcare authorities to enhance their support for providing screening,HBV vaccination,treatment,and educational programs for this populations.

关 键 词：Hepatitis B Chronic hepatitis B virus infection IMMIGRATION Illegal immigrants Refugees ITALY 

分 类 号：R51[医药卫生—内科学]