Prevalence of autoantibodies against cellular antigens in patients with HIV and leprosy coinfection in the Amazon region  

作　　者：Clea Nazare Carneiro Bichara Carlos David Araujo Bichara Camila Tostes Marinete Marins Povoa Juarez Antonio Simoes Quaresma Marilia Brasil Xavier 

机构地区：[1]Center of Biological and Health Sciences,State University of Para,Campus II-CCBS,Rua Perebebui n°2623,Marco,Belem,PA 66087-670,Brazil [2]Evandro Chagas Institute,Ministry of Health,Ananindeua,PA,Brazil [3]Tropical Medicine Center,Federal University of Para,Belem,PA,Brazil

出　　处：《Infectious Diseases of Poverty》2017年第1期704-711,共8页贫困所致传染病（英文）

摘　　要：Background:Infectious agents can activate self-reactive T cells.In general,infections trigger various mechanisms,including a lack of auto-tolerance,induction of costimulatory molecules on antigen presenting cells,and molecular simulation,in addition to cross-reactions between microbial antigens and self-antigens.HIV and leprosy coinfections lead to self-immunity with the production of autoantibodies.However,not enough data on the immune behaviour associated with this coinfection are available.Therefore,this study focused on the detection of autoantibodies against cellular antigens(AACA)in individuals with HIV and leprosy coinfection in the Amazon region.Methods:Patients were distributed into four groups according to their infections:(i)coinfection with HIV and leprosy(n=23),(ii)infection with leprosy(n=33),(iii)infection with HIV/AIDS(n=25),and(iv)healthy blood donor controls(n=100).AACA were identified by indirect immunofluorescence and the samples were tested using a commercial diagnosis kit containing the antinuclear antibody HEp-2.Results:Morphologically,all stages of cell division were assessed in addition to the morphological features associated with the nuclear matrix,nucleolus,mitotic spindle,and cytoplasm.There was a high prevalence of AACA in the coinfection group(47.8%,n=11)when compared with the control group of healthy blood donors(2.0%).The results showed predominantly cytoplasmic staining in all groups analysed,and no difference was observed between the presence or absence of AACA and the leprosy forms(paucibacillary and multibacillary)in the coinfection group.Conclusions:The results of this study show that despite the tendency of coinfected patients to have higher levels of autoantibodies,no correlation was observed between clinical and laboratorial variables and morbidity associated with HIV and leprosy coinfections or the levels of AACA in the serum of coinfected patients.These data are important to elucidate this complex relationship between HIV and leprosy and thus improve the follow-up of the

关 键 词：LEPROSY HIV AUTOANTIBODIES IMMUNOLOGY Amazon region 

分 类 号：R75[医药卫生—皮肤病学与性病学]