Yield of tuberculosis among household contacts of tuberculosis patients in Accra,Ghana  

作　　者：Sally-Ann Ohene Frank Bonsu Nii Nortey Hanson-Nortey Adelaide Sackey Samuel Danso Felix Afutu Paul Klatser Mirjam Bakker 

机构地区：[1]World Health Organization Country Office,29 Volta Street Airport,Airport Residential Area,P.O.Box MB 142,Accra,Ghana [2]National Tuberculosis Control Program,Accra,Ghana [3]Department of Global Health,Academic Medical Centre,Amsterdam Institute of Global Health and Development,Amsterdam,The Netherlands [4]KIT Health,Royal Tropical Institute(KIT),Amsterdam,The Netherlands

出　　处：《Infectious Diseases of Poverty》2018年第1期155-162,共8页贫困所致传染病（英文）

基　　金：The TB case finding intervention was funded by the CIDA,with technical support from the WHO.Funds were not allocated to support these analyses。

摘　　要：Background:The End TB Strategy calls for systematic screening of selected high-risk groups including contacts of tuberculosis(TB)cases to facilitate early TB case detection.Contact investigation is not usually routinely practiced in low TB burden countries,such as Ghana,with consequent paucity of data on the yield of TB case detection from such interventions.This study’s objective was to document the outcomes and feasibility of implementing contact investigation activities under programmatic conditions in Ghana.Methods:Retrospective analyses were conducted of abstracted data from the National TB Program,following a contact investigation intervention for TB cases diagnosed in 10 facilities in Accra from June 2010 to December 2014.Various proportions and yield from number of contacts needed to screen(NNS)and number needed to test(NNT)to detect a TB case were assessed.Results:Overall,out of the 8519 listed contacts of 3267 index cases,8166(96%)were screened and 614(7.5%)were identified as presumptive TB.Out of these,438(71%)underwent sputum smear microscopy/evaluation and 53 TB cases were diagnosed.Of these,56.6%were males,and 49%had sputum smear-positive TB,38%had sputum smear-negative TB,and 7%had extra-pulmonary TB.The NNS and NNT to detect a TB case of all forms were 154 and 8,respectively.The proportion of TB cases with contacts listed and proportion of contacts screened annually were 88-96%and 83-100%,respectively.The proportion of presumptive TB cases tested and proportion of TB cases diagnosed among contacts tested that were 100%and 36%,respectively,in 2010 dropped to 40%and 14%,respectively,by 2014.Conclusions:The study demonstrates that contact identification and prioritization components of a contact investigation were feasible,but overall yield of TB cases may have been lower due to the declining rate of clinical evaluation of presumptive TB contacts over time.Addressing barriers to accessing appropriate diagnostic tests may enhance yield from contact investigation in Ghana.

关 键 词：Ghana TUBERCULOSIS Tuberculosis contact investigation SCREENING 

分 类 号：R72[医药卫生—儿科]