A case report of spontaneous abortion caused by Brucella melitensis biovar 3  

作　　者：Hong-Xia Yang Jun-Jun Feng Qiu-Xiang Zhang Rui-E Hao Su-Xia Yao Rong Zhao Dong-Ri Piao Bu-Yun Cui Hai Jiang 

机构地区：[1]Disease Inspection Laboratory,Shanxi Center for Disease Control and Prevention,Taiyuan,China [2]Clinical Laboratory,Shanxi Dayi Hospital,Taiyuan,China [3]State Key Laboratory for Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China

出　　处：《Infectious Diseases of Poverty》2018年第1期326-329,共4页贫困所致传染病（英文）

基　　金：This study was supported by the Science and Technology Project of the Shanxi Province Health and Family Planning Commission(No.2011077);the National Natural Science Foundation of China(No.81271900);The funders contributed to the study design and data collection.

摘　　要：Background:Brucellosis is a worldwide zoonotic disease caused by Brucella spp.Brucella invades the body through the skin mucosa,digestive tract,and respiratory tract.However,only a few studies on human spontaneous abortion attributable to Brucella have been reported.In this work,the patient living in Shanxi Province in China who had suffered a spontaneous abortion was underwent pathogen detection and Brucella melitensis biovar 3 was identified.Case presentation:The patient in this study was 22 years old.On July 16,2015,she was admitted to Shanxi Grand Hospital,Shanxi Province,China because of one day of vaginal bleeding and three days of abdominal distension accompanied by fever after five months of amenorrhea.A serum tube agglutination test for brucellosis and blood culture were positive.At the time of discharge,she was prescribed oral doxycycline(100 mg/dose,twice a day)and rifampicin(600 mg/dose,once daily)for 6 weeks as recommended by the World Health Organization(WHO).No recurrence was observed during the six months of follow-up after the cessation of antibiotic treatment.Conclusions:This is the first reported case of miscarriage resulting from Brucella melitensis biovar 3 isolated from a pregnant woman who was infected through unpasteurized milk in China.Brucellosis infection was overlooked in the Maternity Hospital because of physician unawareness.Early recognition and prompt treatment of brucellosis infection are crucial for a successful outcome in pregnancy.

关 键 词：Brucella melitensis biovar 3 Spontaneous abortion Human brucellosis 

分 类 号：F42[经济管理—产业经济]