A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection  

作　　者：Kogieleum Naidoo Nonhlanhla Yende-Zuma Stanton Augustine 

机构地区：[1]Centre for the AIDS Programme of Research in South Africa(CAPRISA),Nelson R Mandela School of Medicine,University of KwaZulu-Natal,2nd Floor Doris Duke Medical Research Institute,Private Bag X7,Durban,Congella 4013,South Africa [2]MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit,Doris Duke Medical Research Institute,University of KwaZulu-Natal,Durban,South Africa

出　　处：《Infectious Diseases of Poverty》2018年第1期349-354,共6页贫困所致传染病（英文）

基　　金：Patient care in the CAPRISA AIDS Treatment project is supported by the KwaZulu-Natal Department of Health,the Global Fund to fight AIDS;Tuberculosis and Malaria and the U.S.President’s Emergency Plan for AIDS Relief(PEPFAR);The research infrastructure to conduct this trial,including the data management,laboratory and pharmacy cores were established through the US National Institutes for Health’s Comprehensive International Program of Research on AIDS grant(CIPRA,grant no.:AI51794);KN and SA was supported by the Columbia University-South Africa Fogarty AIDS International Training and Research Program(AITRP,grant no.:D43 TW000231);The funding sources listed here did not have any role in the analysis or preparation of the data in this manuscript,nor was。

摘　　要：Background:High early morbidity and mortality following antiretroviral therapy(ART)initiation has been a distinguishing feature of ART programmes in resource limited settings(RLS)compared to high-income countries.This study assessed how well body mass index(BMI:kg/m^(2))correlated with survival among HIV infected patients with and without TB co-infection.Methods:We retrospectively evaluated clinical data from 1000 HIV infected patients,among whom 389 were also co-infected with TB,between January 2008 and December 2010,in KwaZulu-Natal,South Africa.Results:Among 948 patients eligible for analysis,15.7%(149/948)were underweight(<18.50),55.9%(530/948)had normal BMI(≥18.50-24.90),18.7%(177/948)were overweight(25.00-29.00)and 9.7%(92/948)were obese(≥30.00).Irrespective of TB status,underweight patients,had significantly higher risk of death compared to those with normal BMI at baseline(aHR=2.9;95%CI:1.5-5.7;P=0.002).Conclusions:Irrespective of TB co-infection,low BMI correlated with mortality in HIV infected patients.Trial registration:UKZN Biomedical Research Ethics Committee Reference number E 248/05,23 September 2005.

关 键 词：HIV TUBERCULOSIS BMI ART AFRICA KWAZULU-NATAL KZN South Africa 

分 类 号：R51[医药卫生—内科学]