Distribution of Plasmodium spp.infection in asymptomatic carriers in perennial and low seasonal malaria transmission settings in West Africa  

作　　者：Constant G.N.Gbalegba Hampate Ba Kigbafori D.Silue Ousmane Ba Emmanuel Tia Mouhamadou Chouaibou Nathan T.Y.Tian-Bi Gre goire Y.Yapi Brama Kone Jurg Utzinger Benjamin G.Koudou 

机构地区：[1]Unite de Formation et de Recherche Sciences de la Nature,Universite Nangui Abrogoua,02 B.P.801,Abidjan 02,Cote d’Ivoire [2]Centre Suisse de Recherches Scientifiques en Cote d’Ivoire,01 B.P.1303,Abidjan 01,Cote d’Ivoire. [3]Laboratoire de Parasitologie–Mycologie,Institut National de Recherches en Sante Publique,B.P.695,Nouakchott,Mauritania [4]Unite de Formation et de Recherche Biosciences,Universite Felix Houphouët-Boigny,22 B.P.582,Abidjan 22,Cote d’Ivoire [5]Centre d’Entomologie Me dicale et Veterinaire,Universite Alassane Ouattara,27 B.P.529,Abidjan 27,Cote d’Ivoire [6]UniversitePe le foro Gon Coulibaly,B.P.1328,Korhogo,Cote d’Ivoire [7]Swiss Tropical and Public Health Institute,P.O.Box,CH-4002 Basel,Switzerland [8]University of Basel,P.O.Box,CH-4003 Basel,Switzerland [9]Centre for Neglected Tropical Diseases,Liverpool School of Tropical Medicine,Pembroke Place,Liverpool L35QA,UK

出　　处：《Infectious Diseases of Poverty》2018年第1期374-386,共13页贫困所致传染病（英文）

基　　金：This project received financial support from the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases(TDR)and the Canadian International Development Research Centre(IDRC);grant no.NB20283(Dr.Kone Brama);The funders had no role in study design,data collection and analyses,decision to publish,or preparation of the manuscript.

摘　　要：countries in West Africa remain a hotspot for malaria with all age groups at risk.Asymptomatic carriers of Plasmodium spp.are important sources of infections for malaria vectors and thus contribute to the anchoring of the disease in favourable eco-epidemiological settings.The objective of this study was to assess the asymptomatic malaria case rates in Korhogo and Kaedi,two urban areas in northern Côte d’Ivoire and southern Mauritania,respectively.Methods:Cross-sectional surveys were carried out during the rainy season in 2014 and the dry season in 2015 in both settings.During each season,728 households were randomly selected and a household-based questionnaire was implemented to collect demographic and epidemiological data,including of malaria preventive methods used in communities.Finger-prick blood samples were obtained for biological examination using microscopy and rapid diagnostic tests(RDTs).Results:Overall,2672 households and 15858 consenting participants were surveyed.Plasmodium spp.infection was confirmed in 12.4%(n=832)and 0.3%(n=22)of the assessed individuals in Korhogo and Kaedi,respectively.In Korhogo,the prevalence of asymptomatic malaria was 10.5%(95%CI:9.7-11.2)as determined by microscopy and 9.3%(95%CI:8.6-10.0%)when assessed by RDT.In Kaedi,asymptomatic malaria prevalence was 0.2%(95%CI:0.1-0.4%)according to microscopy,while all RDTs performed were negative(n=8372).In Korhogo,asymptomatic malaria infection was significantly associated with age and season,with higher risk within the 5-14 years-old,and during the rainy season.In Kaedi,the risk of asymptomatic malaria infection was associated with season only(higher during the dry season;crude OR(cOR):6.37,95%CI:1.87-21.63).P.falciparum was the predominant species identified in both study sites representing 99.2%(n=825)in Korhogo and 59.1%(n=13)in Kaedi.Gametocytes were observed only in Korhogo and only during the rainy season at 1.3%(95%CI:0.7-2.4%).Conclusions:Our findings show a low prevalence of clinical malaria episodes with a significant p

关 键 词：Plasmodium spp. Asymptomatic carriers Urban area Rapid diagnostic tests Microscopy Côte d’Ivoire MAURITANIA Korhogo Kaedi 

分 类 号：R53[医药卫生—内科学]