Co-morbidity of malnutrition with falciparum malaria parasitaemia among children under the aged 6-59 months in Somalia:a geostatistical analysis  

作　　者：Damaris K.Kinyoki Grainne M.Moloney Olalekan A.Uthman Elijah O.Odundo Ngianga-Bakwin Kandala Abdisalan M.Noor Robert W.Snow James A.Berkley 

机构地区：[1]Spatial Health Metrics Group,INFORM Project,Kenya Medical Research Institute/Wellcome Trust Research Programme,Nairobi,Kenya [2]Nutrition Section,United Nations Children’s Fund(UNICEF),Kenya Country Office,UN Complex Gigiri,Nairobi,Kenya [3]Warwick Medical School,Health Sciences Research Institute,Warwick Evidence,University of Warwick,Gibbet Hill,Coventry CV47AL,UK [4]Food Security and Nutrition Analysis Unit(FSNAU)-Somalia,Food and Agriculture Organization of the United Nations,Ngecha Road Campus,Nairobi,Kenya [5]Department of Mathematics and Information sciences,Faculty of Engineering and Environment,Northumbria University,Newcastle upon Tyne,UK [6]Faculty of Health and Sport Sciences,University of Agder,Kristiansand,Norway [7]Division of Epidemiology and Biostatistics,School of Public Health,University of the Witwatersrand,Johannesburg,South Africa [8]Kenya Medical Research Institute/Wellcome Trust Research Programme,Centre for Geographic Medicine Research(coast),Kilifi,Kenya [9]Centre for Tropical Medicine and Global Health,Nuffield Department of Clinical Medicine,University of Oxford,CCVTM,Oxford OX37LJ,UK

出　　处：《Infectious Diseases of Poverty》2018年第1期714-722,共9页贫困所致传染病（英文）

基　　金：AMN was supported by a Wellcome Trust grant(No.:095127)that also supported DKK.DKK was also supported by a Sustaining Health award from the Wellcome Trust(No.:103926);RWS is supported as a Wellcome Trust Principal Fellow(No.:10360);JAB is supported by the Bill&Melinda Gates Foundation(No.:OPP1131320).

摘　　要：Background:Malnutrition and malaria are both significant causes of morbidity and mortality in African children.However,the extent of their spatial comorbidity remains unexplored and an understanding of their spatial correlation structure would inform improvement of integrated interventions.We aimed to determine the spatial correlation between both wasting and low mid upper arm circumference(MUAC)and falciparum malaria among Somalian children aged 6-59 months.Methods:Data were from 49227 children living in 888 villages between 2007 to 2010.We developed a Bayesian geostatistical shared component model in order to determine the common spatial distributions of wasting and falciparum malaria;and low-MUAC and falciparum malaria at 1×1 km spatial resolution.Results:The empirical correlations with malaria were 0.16 and 0.23 for wasting and low-MUAC respectively.Shared spatial residual effects were statistically significant for both wasting and low-MUAC.The posterior spatial relative risk was highest for low-MUAC and malaria(range:0.19 to 5.40)and relatively lower between wasting and malaria(range:0.11 to 3.55).Hotspots for both wasting and low-MUAC with malaria occurred in the South Central region in Somalia.Conclusions:The findings demonstrate a relationship between nutritional status and falciparum malaria parasitaemia,and support the use of the relatively simpler MUAC measurement in surveys.Shared spatial distribution and distinct hotspots present opportunities for targeted seasonal chemoprophylaxis and other forms of malaria prevention integrated within nutrition programmes.

关 键 词：MALNUTRITION WASTING Low-MUAC Malaria COMORBIDITY SOMALIA 

分 类 号：R53[医药卫生—内科学]