Rabies virus transmission via solid organs or tissue allotransplantation  

作　　者：Xue-Xin Lu Wu-Yang Zhu Gui-Zhen Wu 

机构地区：[1]National Institute For Viral Disease Control and Prevention,Chinese Center For Disease Control and Prevention,155 Changbai Road Changping District,Beijing,People’s Republic of China

出　　处：《Infectious Diseases of Poverty》2018年第1期822-829,共8页贫困所致传染病（英文）

基　　金：This study was financially supported by the National Key R&D Program of China(grant No.2017YFC1200503);the National Key Research Program(grant No.2016YFD0500400 and grant No.2017ZX10104001).

摘　　要：Background:Rabies,for which the mortality rate is almost 100%,is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation.Dozens of deaths from rabies via solid organs or tissues allotransplantation(ROTA)have been documented during the last decades.In 2015 and 2016,two cases of rabies virus transmission via solid organs or tissue allotransplantation were reported in China,which further underscore the risk and importance of this special type of rabies for organ transplant recipients.Main text:From 1978 to 2017,at least 13 cases of ROTA,causing dozens of deaths,have been reported worldwide,whether in the high-risk or low-risk countries of rabies.The reported incubation period of ROTA ranges from 11 days to more than 17 months,while the historical incubation period of rabies is generally considered to range from~1 week to several years.The pathogenesis of ROTA is not clear,but the use of post-exposure prophylaxis(PEP)can play a protective role in the transplant recipients.We also summarize reports about ROTA in China,combined with the actual situation regarding work on rabies surveillance and elimination,and suggest countermeasures for the prevention and control of ROTA in the future.Conclusions:Understanding the significance of ROTA,screening the suspected organs,assessing the risk and protecting the related population will be effective way to prevent and control further occurrence of ROTA.

关 键 词：RABIES Solid organ or tissue allotransplantation Donor RECIPIENT ZOONOSIS 

分 类 号：R51[医药卫生—内科学]