美沙拉嗪-Fe^(3+)络合体系的光谱特征及分析应用  

Spectral characteristics of mesalazine-Fe^(3+) complexation and its analytical application

作　　者：林瑜 王兵[2] LIN Yu;WANG Bing(Faculty of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530001;The First Clinical Faculty of Guangxi University of Chinese Medicine,Nanning 530023)

机构地区：[1]广西中医药大学药学院,南宁530001 [2]广西中医药大学第一附属医院,南宁530023

出　　处：《分析试验室》2021年第8期881-884,共4页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(81804099);广西壮瑶药重点实验室子项目(GXZYKF2019-7)资助。

摘　　要：pH 3.0时,美沙拉嗪与Fe^(3+)以2:1形成稳定的紫红色络合物,该络合物在505 nm产生特征吸收,稳定常数K=1.78×10^(8)L^(2)/mg^(2)。在16.45~995.4μg/m L的范围内,络合物的吸光度与药物的浓度呈良好的线性关系,A=0.9141c+0.1746,r=0.9909,检出限为4.56μg/m L,据此建立了一种基于Fe^(3+)络合的紫外-可见分光光度法测定美沙拉嗪的方法。用该方法对市售美沙拉嗪肠溶片及美沙拉嗪颗粒进行测定,测定值与药品标示值相符,加标回收率在96%~106%。Mesalazine could react with Fe^(3+)to form a stable purplish red complex in a ratio of 2:1 at pH 3.0,which could produce characteristic absorb at 505 nm.The stability constant of complex is 1.78×10^(8)L^(2)/mg^(2).In the range of 16.45-995.4μg/m L,there was a good linear relationship between the absorbance of the complex and the concentration of the mesalazine.The linear equation was A=0.9141 c+0.1746,with the correlation coefficient of 0.9909,and the detection limit of 4.56μg/m L.A new method has been built based on UV-Vis with Fe^(3+)as the medium to determine the content of mesalazine.The method has been successfully applied to the determination of commercial pharmaceutical preparations,and the measured values were basically consistent with the labeled amount of drugs,the recoveries were in the range of 96%-106%.

关 键 词：美沙拉嗪 Fe^(3+) 络合 紫外-可见分光光度法 

分 类 号：O657.32[理学—分析化学]