Killing filarial nematode parasites: role of treatment options and host immune response  

作　　者：Alexander Kwarteng Samuel Terkper Ahuno Freda Osei Akoto 

机构地区：[1]Kumasi Centre for Collaborative Research in Tropical Medicine(KCCR),PMB,KNUST,Kumasi,Ghana [2]Department of Biochemistry and Biotechnology,Kwame Nkrumah University of Science Technology,PMB,Kumasi,Ghana

出　　处：《Infectious Diseases of Poverty》2016年第1期793-798,共6页贫困所致传染病（英文）

摘　　要：Background:There is compelling evidence that not only do anti-filarials significantly reduce larval forms,but that host immune responses also contribute to the clearance of filarial parasites;however,the underlying mechanisms have not been fully elucidated.Main text:Filarial infections caused by Wuchereria bancrofti and Brugia species(lymphatic filariasis)and Onchocerca volvulus(onchocerciasis)affect almost 200 million individuals worldwide and pose major public health challenges in endemic regions.Indeed,the collective disability-adjusted life years for both infections is 3.3 million.Infections with these thread-like nematodes are chronic and,although most individuals develop a regulated state,a portion develop severe forms of pathology.Mass drug administration(MDA)programmes on endemic populations focus on reducing prevalence of people with microfilariae,the worm's offspring in the blood,to less than 1%.Although this has been successful in some areas,studies show that MDA will be required for longer than initially conceived.Conclusion:This paper highlights the mode of action of the various antifilarial treatment strategies and role of host immune response.

关 键 词：Ivermectin Lymphatic filariasis Onchocerciasis Immune response Abbreviations:ALB Albendazole DEC Diethlycarbamazine IVM Ivermectin LF Lymphatic filariasis MDA Mass drug administration MF Microfilariae TPE Tropical pulmonary eosinophilia 

分 类 号：R53[医药卫生—内科学]