茵陈汤合甘露消毒丹加减对慢性乙型病毒性肝炎湿热蕴蒸证的疗效及肠道菌群的影响  

Curative Effect of Yinchen Tang and Modified Ganlu Xiaodu Pills on Chronic Hepatitis B with Syndrome of Dampness-Heat Amassing and Steaming and Its Effect on Intestinal Flora

作　　者：曾志涛 ZENG Zhitao

机构地区：[1]温岭市第一人民医院感染科,浙江温岭317500

出　　处：《新中医》2021年第15期12-16,共5页New Chinese Medicine

摘　　要：目的:观察茵陈汤合甘露消毒丹加减治疗慢性乙型病毒性肝炎湿热蕴蒸证的疗效以及对肠道菌群的影响。方法:纳入82例慢性乙型病毒性肝炎湿热蕴蒸证患者作为研究对象,按随机数字表法分为对照组及观察组各41例。对照组给予恩替卡韦片治疗,观察组在恩替卡韦片治疗基础上给予茵陈汤合甘露消毒丹加减。2组均治疗12周。比较2组的临床疗效,观察2组治疗前后肝功能、湿热蕴蒸证主症评分及肠道菌群的变化。结果:治疗12周,观察组临床疗效总有效率为95.12%,对照组为75.61%,2组比较,差异有统计学意义(P<0.05)。2组谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(GGT)水平均较治疗前降低(P<0.01),观察组上述指标值均低于对照组(P<0.01)。2组身目黄染、小便黄赤、口干苦评分均较治疗前下降(P<0.01),观察组3项症状评分均低于对照组(P<0.01)。2组双歧杆菌、乳酸杆菌拷贝数均较治疗前升高,大肠杆菌、肠球菌拷贝数均较治疗前减少(P<0.01),观察组双歧杆菌、乳酸杆菌、大肠杆菌、肠球菌的改善情况均优于对照组(P<0.01)。结论:茵陈汤合甘露消毒丹加减治疗慢性乙型病毒性肝炎湿热蕴蒸证的疗效显著,可有效缓解症状,调节肠道菌群数量,改善肝功能。Objective:To observe the curative effect of Yinchen tang and modified Ganlu Xiaodu pills on chronic hepatitis B with syndrome of dampness-heat amassing and steaming and its effect on intestinal flora.Methods:A total of 82 cases of patients with chronic hepatitis B with syndrome of dampness-heat amassing and steaming were enrolled as the study objects,and divided into the control group and the observation group according to the random number table method,41 cases in each group.The control group was given entecavir tablets,and the observation group was additionally given Yinchen tang and modified Ganlu Xiaodu pills based on the treatment of the control group.Both groups were treated for 12 weeks.The clinical effect was compared between the two groups.Before and after treatment,changes in the lung function,the main symptom scores of syndrome of dampness-heat amassing and steaming,and levels of intestinal flora were observed in the two groups.Results:After twelve-week treatment,the total effective rate was 95.12% in the observation group,and 75.61%in the control group,the difference being significant(P<0.05).Levels of Aspartate aminotransferase(AST),Alanine aminotransferase(ALT),and γ-glutamyl transpeptidase(GGT)in the two groups were decreased when compared with those before treatment(P<0.01),and the three levels above in the observation group were lower than those in the control group(P<0.01).Scores of yellow skin and eye,reddish yellow urine,dry mouth and bitter taste in the mouth in the two groups were decreased when compared with those before treatment(P<0.01),and the three symptom scores in the observation group were lower than those in the control group(P<0.01).The copy number of bifidobacterium and lactobacillus in the two groups was increased when compared with that before treatment,and copy number of escherichia coli and enterococcus were decreased(P<0.01);the improvement of bifidobacterium,lactobacillus,escherichia coli,and enterococcus in the observation group was better than that in the control group(P<

关 键 词：慢性乙型病毒性肝炎 湿热蕴蒸证 茵陈汤 甘露消毒丹 肠道菌群 

分 类 号：R512.62[医药卫生—内科学]