CD64、CHE及sCD14在股骨转子间骨折术后感染中的表达及意义  

The expression and significance of CD64,CHE and sCD14 in the postoperative infection of patients with intertrochanteric fracture

作　　者：许梅辛 孙兴霞[2] 刘洋[1] 常亮 曹雪丹 XU Meixin;SUN Xingxia;LIU Yang;CHANG Liang;CAO Xuedan(Department of Orthopedics,the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang,China,150040;Department of Community Medicine,the Fourth Affili-ated Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150040)

机构地区：[1]黑龙江中医药大学附属第一医院骨科,黑龙江哈尔滨150040 [2]哈尔滨医科大学附属第四医院社区医学科,黑龙江哈尔滨150040

出　　处：《分子诊断与治疗杂志》2021年第8期1293-1296,共4页Journal of Molecular Diagnostics and Therapy

基　　金：黑龙江省自然科学基金项目(H2018013)。

摘　　要：目的探究CD64、胆碱酯酶(CHE)及可溶性白细胞分化抗原⁃14(sCD14)在股骨转子间骨折术后感染中的表达及意义。方法选取本院2019年6月至2020年6月收治的105例股骨转子间骨折患者,根据术后是否发生感染分为感染组(n=22)与未感染组(n=83)。比较两组CD64指数、CHE及sCD14水平,分析影响股骨转子间骨折术后感染的危险因素,并绘制受试者工作特征曲线(ROC),分析上述因子水平诊断老年股骨转子间骨折患者术后感染的价值。结果105例患者中,22例术后发生感染(20.95%),83例术后未发生感染(79.05%)。感染组CD64指数、CHE及sCD14水平均显著高于未感染组,差异具有统计学意义(P<0.05)。多元Logistic回归分析示CD64指数(升高)、CHE(升高)及sCD14(升高)为影响股骨转子间骨折术后感染的独立危险因素(P<0.05)。ROC曲线分析结果显示,CD64指数、CHE及sCD14单纯检测的曲线下面积(AUC)分别为0.631、0.618、0.734,均低于三者联合检测0.761(P<0.05)。结论CD64指数、CHE及sCD14在老年股骨转子间骨折术后感染中呈异常表达,联合检测可有效预测术后感染情况。Objective To explore the expression and significance of CD64,cholinesterase(CHE)and soluble cluster of differentiation antigen⁃14(sCD14)in the postoperative infection of patients with intertrochanteric fracture.Methods The 105 patients with intertrochanteric fractures admitted in this hospital from June 2019 to June 2020 were selected.The patients were divided into the infected group and the non⁃in⁃fected group according to whether infection occurred after operation.The CD64 index,CHE and sCD14 levels between the two groups were compared.The risk factors affecting postoperative infection of patients with inter⁃trochanteric fracture were analyzed.The receiver operating characteristic curve(ROC)was drawn to analyze the value of the above factors in the diagnosis of postoperative infection in elderly patients with intertrochanter⁃ic fractures.Results of the 105 patients,22 cases developed infections after surgery(20.95%),83 cases did not develop infections after surgery(79.05%).The CD64 index,CHE and sCD14 levels of the infected group were significantly higher than those of the non⁃infected group,and the difference was statistically significant(P<0.05).Multivariate logistic regression analysis showed that CD64 index(increased),CHE(increased)and sCD14(increased)were independent risk factors affecting postoperative infection of patients with intertrochanteric fractures(P<0.05).The results of ROC curve analysis showed that the areas under the curve(AUC)of the CD64 index,CHE,and sCD14 detection alone were 0.631,0.618,and 0.734,respectively,which were all lower than the combined detection of the three at 0.761(P<0.05).Conclusion The CD64 index,CHE,and sCD14 are abnormally expressed in elderly patients with postoperative infection of intertrochanteric fractures.The combined detection can effectively predict postoperative infection.

关 键 词：CD64指数 胆碱酯酶 可溶性白细胞分化抗原⁃14 股骨转子间骨折 术后感染 

分 类 号：R687.3[医药卫生—骨科学]