心磷脂变化参与非酒精性脂肪性肝病相关线粒体功能障碍的发生和发展  

Changes of cardiolipin involve in the occurrence and development of mitochondrial dysfunction associated with non-alcoholic fatty liver disease

作　　者：吴敏[1] 陈联辉[1] 陈郎湖 汪勇芬[1] WU Min;CHEN Lianhui;CHEN Langhu;WANG Yongfen(Department of Pediatrics,Second Affiliated Hospital of Fujian Medical University,Quanzhou Fujian 362000,China)

机构地区：[1]福建医科大学附属第二医院儿科,福建泉州362000

出　　处：《中南大学学报（医学版）》2021年第6期653-657,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81803595)。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是最常见的肝疾病之一,其发生常伴随着线粒体功能障碍。心磷脂作为线粒体内膜的特殊脂质,其任何改变都有可能引起一系列线粒体相关疾病。心磷脂含量的变化、心磷脂重构后脂肪酸侧链的组成变化及心磷脂重构酶的含量改变在NAFLD相关线粒体功能障碍的发生和发展中发挥着重要的作用。Non-alcoholic fatty liver disease(NAFLD) is one of the most common liver diseases,which is often accompanied by mitochondrial dysfunction. Cardiolipin is a special lipid of mitochondrial inner membrane and any change of cardiolipin may cause series of mitochondria-relevant diseases. Changes in cardiolipin content, fatty acid side chain composition after cardiolipin remodeling, and the content of cardiolipin remodeling enzymes play an important role in the occurrence and development of NAFLD-related mitochondrial dysfunction.

关 键 词：非酒精性脂肪性肝病 线粒体功能障碍 心磷脂 

分 类 号：R575.5[医药卫生—消化系统]