MR征象与乳腺癌VEGF表达的相关性分析  

Correlation between preoperative MRI signs and vascular endothelial growth factor expression in breast cancer

作　　者：朱景航 高小玲[1] ZHU Jing-hang;GAO Xiao-ling(Department of Radiology,Wuhan No.1 Hospital,Hubei 430000,China)

机构地区：[1]武汉市第一医院放射科,湖北武汉430022

出　　处：《影像诊断与介入放射学》2021年第4期261-265,共5页Diagnostic Imaging & Interventional Radiology

摘　　要：目的探讨术前磁共振征象与乳腺癌血管内皮生长因子(VEGF)的相关性,为VEGF的影像学预测提供参考依据。方法对73例乳腺癌患者术前磁共振资料进行回顾性分析,依据VEGF表达情况,分为VEGF高表达与VEGF低表达组。对两组患者临床病理以及术前MRI资料进行单因素分析,并通过Logistic回归方程建立多因素分析诊断模型,计算出该模型诊断乳腺癌VEGF的独立预测因素。结果乳腺癌患者VEGF(高表达)28例、VEGF(低表达)45例;单因素分析结果显示:乳腺癌VEGF的表达与乳腺癌分子亚型、组织分级以及淋巴结转移密切相关(均P<0.05);此外,VEGF的表达与MR征象肿块类型、ADC值、时间信号曲线(TIC)无关(均P>0.05),而与肿瘤直径、环形强化、瘤内高信号、瘤周水肿密切相关(均P<0.05)。Logistic回归方程多因素分析结果显示:组织分级(OR=10.296,P=0.005)、环形强化(OR=10.819,P=0.030)、瘤周水肿(OR=15.297,P=0.012)是诊断乳腺癌VEGF的独立预测因素(Hosmer-Lemeshow,χ^(2)=5.224,P=0.733)。结论VEGF表达与乳腺癌多种恶性生物学行为密切相关,磁共振环形强化、瘤周水肿征是乳腺癌VEGF表达的独立预测因素。Objective To investigate the correlation between preoperative MRI signs and vascular endothelial growth factor(VEGF)in breast cancer,and to provide reference for the prediction of VEGF.Methods The preoperative MRI of 73 patients with breast cancer was retrospectively analyzed.The patients were divided into VEGF over expression(28)and VEGF low expression(45)groups.Clinicopathological and preoperative MR data of the two groups were analyzed by univariate analysis,and a multivariate diagnostic model was established by logistic regression equation.Independent predictors of the model for the diagnosis of VEGF in breast cancer were calculated.Results The results of univariate analysis showed that the expression of VEGF in breast cancer was closely related to the molecular subtype,histological grade and lymph node metastasis of breast cancer(P<0.05).The expression of VEGF was not correlated(P>0.05)with the type of tumor,apparent diffusion coefficient value and time signal curve,but was closely related to tumor diameter,ring enhancement,intratumoral hyperintensity and peritumoral edema(P<0.05).Multivariate logistic regression analysis showed that histological classification(OR=10.296,P=0.005),peripheral rim enhancement(OR=10.819,P=0.030),and peritumoral edema(OR=15.297,P=0.012)were independent predictors of VEGF in breast cancer(Hosmer-Lemeshow,χ^(2)=5.224,P=0.733).Conclusion The expression of VEGF is closely related to many malignant biological behaviors of breast cancer.Preoperative MRI sign of peripheral rim enhancement and peritumoral edema can be independent predictor of VEGF expression in breast cancer.

关 键 词：术前磁共振征象 乳腺癌 血管内皮生长因子 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]