黑皮质素受体4激动剂的研究进展  

Research Progress of Melanocortin-4 Receptor Agonist

作　　者：赵宏丽 冯贵龙[2] ZHAO Hongli;FENG Guilong(Shanxi Medical University,Taiyuan 030001,China;Department of Emergency,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第一医院急诊科,太原030001

出　　处：《中国现代应用药学》2021年第13期1634-1638,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：国家临床重点专科建设项目(国卫办医函[2013]544号)。

摘　　要：黑皮质素受体4(melanocortin-4 receptor,MC4R)是一种参与中枢调节的G蛋白偶联受体,主要存在于皮质、丘脑、下丘脑、脑干。激活MC4R可产生多种生理功能,因此本文就近年来新发现的外源性MC4R激动剂RM-493、RO27-3225和PT-141的生理功能及其研究进展做一综述,旨在为今后临床用药提供参考。Melanocortin-4 receptor(MC4R) is a G-protein-coupled receptor involved in central regulation, which mainly exists in cortex, thalamus, hypothalamus and brain stem. Activation of MC4R can produce a variety of physiological functions, so the recent discovery of exogenous MC4R agonists RM-493, RO27-3225 and PT-141 as well as their physiological functions and research progress are reviewed in this paper to reference evidence for future clinical use.

关 键 词：黑皮质素受体4 RM-493 RO27-3225 PT-141 

分 类 号：R961[医药卫生—药理学]