基因芯片技术在中药现代化研究中的应用进展  

Application of Gene Chip Technology in the Modernization of Traditional Chinese Medicine

作　　者：刘玉峰[1,2] 许肈初 马海燕 LIU Yu-feng;XU Zhao-chu;MA Hai-yan(School of Pharmacy,Liaoning University,Shenyang 110036,China;Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning Province,Shenyang 110036,China)

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]辽宁省天然产物制药工程技术研究中心,辽宁沈阳110036

出　　处：《辽宁大学学报（自然科学版）》2021年第3期254-262,共9页Journal of Liaoning University：Natural Sciences Edition

基　　金：国家自然科学基金青年科学基金项目(81403177);辽宁省高等学校创新人才支持计划(LR2018047);沈阳市科技局应用基础项目(F12-277-1-14)。

摘　　要：高通量基因芯片技术是一种高度集成化的分析和研究技术,是进行药物基因组学研究的主要平台.而中药是中华民族的宝藏,已有几千年的发展历史,将基因芯片技术应用到中药研究中是中医全息性思维的体现,会从根本上改变长期以来人们对中药的认识层次和研究手段,是中药研究领域中一次具有深远意义的改革,将为中药现代化的发展提供新的途径.近年来,国内外已有一些将基因芯片技术应用到中药研究的报道,从中医传统思维的角度探讨基因芯片技术应用在中药现代化研究,讨论利用基因芯片进行中药有效成分筛选及新药研发、中药作用机理研究、中药复方研究、中药质量控制及安全性评价、中药基因组学研究和药效变化方面的应用,为中药现代化研究提供参考.As a highly integrated analytical and research tool,gene chip technology is the main platform for pharmacogenomics research.Traditional Chinese Medicine(TCM)is a treasure of the China and has been developed for thousands of years.The level of understanding and research methods of TCM will be substantially changed by the application of this gene chip technology,which shows the holographic thought of TCM.It is a far-reaching reform in the field of Chinese medicine research and will provide new ways for the development of modernization of Chinese medicine.In recent years,domestic and overseas scholars have many reports on the application of gene chip technology to TCM research.This paper will review its application of this gene chip technology in the research of modernization,which shows the holographic thought of TCM,screening of effective components,mechanism of action,complex prescription,quality control and safety evaluation,genomics of TCM and Efficacy of change in TCM.It provides strong technical support for the modernization of TCM.

关 键 词：基因芯片 中药现代化 中药作用机制 中药成分筛选 

分 类 号：R932[医药卫生—生药学]