亚洲地区维持性血液透析患者肌少症患病率及影响因素的Meta分析  

Meta analysis of the prevalence and influencing factors of sarcopenia in maintenance hemodialysis patients in Asia

作　　者：何莉[1,2] 陈林 张颖君[1,2] 陈辉[1,2] 李超 HE Li;CHEN Lin;ZHANG Ying-jun;CHEN Hui;LI Chao(Hemodialysis Center,Department of Nephrology,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China;West China School of Nursing,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院肾脏内科血液透析中心,国家老年疾病临床医学研究中心,成都610041 [2]四川大学华西护理学院,成都610041

出　　处：《中国血液净化》2021年第7期455-459,共5页Chinese Journal of Blood Purification

基　　金：国家老年疾病临床医学研究中心(四川大学华西医院)立项资助课题(Z20192012)。

摘　　要：目的系统评价亚洲地区维持性血液透析患者肌少症的患病率和影响因素。方法计算机检索PubMed、Embase、Web of science、Cochrane Library、中国知网、中国生物医学文献数据库、维普和万方数据库从建库至2020年10月关于亚洲地区维持性血液透析(maintenance hemodialysis,MHD)患者肌少症影响因素的研究,使用Stata 15.1软件进Meta分析。结果共纳入10篇文献,研究对象1830例,文献质量为中高等。Meta分析显示亚洲地区MHD患者肌少症的患病率为33%(95%CI:0.227~0.428),其中国内MHD患者肌少症的患病率为32%(95%CI:0.198~0.437)。年龄(OR=0.850,95%CI:0.630~1.070,P<0.001)、透析龄(OR=0.396,95%CI:0.090~0.701,P=0.011)、改良主观全面营养评价(OR=0.886,95%CI:0.694~1.077,P<0.001)、血清磷(OR=﹣0.613,95%CI:﹣0.877~﹣0.349,P<0.001)与肌少症独立相关。结论亚洲地区MHD患者肌少症的患病率较高,高龄、长透析龄、营养不良及低血清磷水平是MHD患者肌少症发生的危险因素,应对此类患者及早进行干预。Objective A systematic review of the prevalence and influencing factors of sarcopenia in maintenance hemodialysis(MHD)patients in Asia.Methods Computer search of PubMed,Embase,Web of Science,Cochrane Library,CNKI,China Biomedical Literature Database,VIP and Wanfang Database from the establishment of the database to October 2020 for the prevalence and influencing factors of sarcopenia in maintenance hemodialysis(MHD)patients in Asia was conducted.Stata 15.1 software was used for meta analysis.Results A total of 10 articles were enrolled,including 1,830 subjects,and the quality of the literature was medium to high.Meta analysis showed that the prevalence of sarcopenia in MHD patients in Asia was 33%(95%CI 0.227~0.428),and the prevalence of sarcopenia in MHD patients in China was 32%(95%CI 0.198~0.437).The influencing factors of sarcopenia included age(OR=0.850,95%CI 0.630~1.070,P<0.001),dialysis duration(OR=0.396,95%CI 0.090~0.701,P=0.011),modified quantitative subjective global nutrition evaluation assessment(MQSGA)score(OR=0.886,95%CI 0.694~1.077,P<0.001)and serum phosphorus(OR=-0.613,95%CI-0.877~-0.349,P<0.001).Conclusion The prevalence of sarcopenia in MHD patients in Asia was high.Older age,longer dialysis age,malnutrition,and lower serum phosphorus level were the risk factors for sarcopenia in MHD patients.Sarcopenia in MHD patients should be treated as early as possible.

关 键 词：肌少症 血液透析 影响因素 META分析 

分 类 号：R459.5[医药卫生—治疗学]