乳腺癌患者血浆凝血四项水平的变化及临床意义  

Changes and clinical significance of four plasma coagulation levels in patients with breast cancer

作　　者：颜丙芳 夏兰兰 孟玮[1] YAN Bingfang;XIA Lanlan;MENG Wei(Clinical Medicine Laboratory,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China)

机构地区：[1]滨州医学院附属医院临床医学实验室,山东滨州256603

出　　处：《滨州医学院学报》2021年第4期270-271,274,共3页Journal of Binzhou Medical University

摘　　要：目的探讨乳腺癌患者凝血四项指标即血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)的水平变化与乳腺良性肿瘤、病理类型及远处淋巴结转移的关系,以利于对乳腺癌患者病情和预后的评估。方法选取乳腺癌患者100例为试验组,同期收治的乳腺良性肿瘤患者100例为对照组,检测比较两组患者治疗前血浆凝血四项的水平,以及乳腺癌患者不同病理类型及是否远处转移各指标水平的变化情况。结果试验组血浆TT水平明显高于对照组,P<0.05;而PT、APTT和FIB的差异均无统计学意义。此外,不同病理类型及有无远处淋巴结转移的乳腺癌患者其凝血四项水平差异不具有统计学意义。结论乳腺癌患者的TT水平明显高于乳腺良性肿瘤患者,监测乳腺癌患者血浆TT水平有助于对患者病情及预后进行更好地评估。Objective To investigate the relationship between the changes of plasma prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB)and breast benign tumor,pathological type and distant lymph node metastasis in patients with breast cancer,so as to evaluate the condition and prognosis of patients with breast cancer.Methods One hundred patients with breast cancer were selected as the experimental group and 100 patients with benign breast tumor treated in the same period as the control group.The levels of four items of plasma coagulation were detected and compared between the two groups before the treatment,as well as the changes of different pathological types and distant metastasis in patients with breast cancer.Results The level of plasma TT in the experimental group was significantly higher than that in the control group,with P<0.05,but there was no significant difference in PT,APTT and FIB.In addition,there was no significant difference in four coagulation levels among breast cancer patients with different pathological types and with or without distant lymph node metastasis.Conclusion The level of TT in patients with breast cancer is significantly higher than that in patients with benign breast tumor.Monitoring the level of plasma TT in patients with breast cancer is helpful to better evaluate the condition and prognosis of patients with breast cancer.

关 键 词：乳腺癌 凝血酶原时间 活化部分凝血活酶时间 凝血酶时间 纤维蛋白原 

分 类 号：R446.1[医药卫生—诊断学]