滋肾降糖丸联合阿仑膦酸钠治疗老年糖尿病性骨质疏松的效果及其对血清B-ALP、OC、β-CTX、OPG水平的影响  

Efficacy of Zishen Jiangtang Pill combined with alendronate sodium on senile diabetic osteoporosis and its impacts on the levels of serum B-ALP,OC,β-CTX and OPG

作　　者：杨震宇 YANG Zhenyu(DepartmentⅡof Endocrinology,Jiamusi Central Hospital in Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院二部内分泌科,黑龙江佳木斯154002

出　　处：《中国现代医生》2021年第21期86-89,共4页China Modern Doctor

摘　　要：目的探讨滋肾降糖丸联合阿仑膦酸钠治疗老年糖尿病性骨质疏松(DOP)的效果及其对血清B-ALP、OC、β-CTX、OPG水平的影响。方法收集2018年3月至2020年4月本院收治的老年DOP患者74例,采用随机数字表法分为两组,每组各37例。对照组在常规降糖治疗基础上加服阿仑膦酸钠治疗,观察组在对照组基础上加服滋肾降糖丸治疗,比较两组血糖、股骨颈骨密度(BMD)、疗效、骨代谢指标及不良反应。结果治疗后,两组FPG、2 hPPG均降低,股骨颈BMD均升高,且观察组FPG、2 hPPG低于对照组,股骨颈BMD高于对照组,差异有统计学意义(P<0.05);观察组总有效率为94.59%,高于对照组的78.38%,差异有统计学意义(P<0.05);治疗后,两组血清B-ALP、OC、OPG水平均升高,β-CTX水平降低,且观察组血清B-ALP、OC、OPG水平均高于对照组,β-CTX水平低于对照组,差异均有统计学意义(P<0.05);两组均未见明显不良反应。结论滋肾降糖丸联合阿仑膦酸钠治疗老年DOP的效果确切,可有效控制血糖,提高骨密度,改善骨代谢指标,安全有效。Objective To investigate the efficacy of Zishen Jiangtang Pill combined with alendronate sodium on senile diabetic osteoporosis(DOP)and its impacts on the levels of serum B-ALP,OC,β-CTX and OPG.Methods A total of 74 senile patients with DOP admitted to our hospital from March 2018 to April 2020 were collected,and they were divided into the control group and the observation group with 37 cases in each group according to the random number table method.The control group was treated with alendronate sodium on the basis of the conventional hypoglycemic therapy,while the observation group was treated with Zishen Jiangtang Pill on the basis of the control group.The blood glucose,bone mineral density(BMD)of femoral neck,therapeutic efficacy,bone metabolism index and adverse reactions(ADRs)were compared between the two groups.Results After treatment,FPG and 2 hPPG of the two groups both decreased,and BMD of femoral neck both increased.Meanwhile,FPG and 2 hPPG in the observation group were lower and BMD of femoral neck was higher than those in the control group,with statistically significant differences(P<0.05).The total effective rate of the observation group was 94.59%,which was higher than that of 78.38%in the control group(P<0.05).After treatment,the levels of serum B-ALP,OC and OPG all increased andβ-CTX decreased in the two groups.And the levels of serum B-ALP,OC and OPG in the observation group were all higher than those in the control group,but the level ofβ-CTX was lower than that in the control group,all with statistically significant differences(P<0.05).No obvious ADRs were found in both groups.Conclusion Zishen Jiangtang Pill combined with alendronate sodium has a definite effect in the treatment of senile DOP.It can effectively control blood glucose,increase BMD and improve bone metabolism index.Therefore,it is safe and effective.

关 键 词：滋肾降糖丸 阿仑膦酸钠 糖尿病 骨质疏松 骨代谢 

分 类 号：R684.3[医药卫生—骨科学] R580[医药卫生—外科学]