宫腔灌注人粒细胞集落刺激因子对薄型子宫内膜患者冻融胚胎移植结局的影响  

Effect of intrauterine perfusion of human granulocyte colony stimulating factor on outcome of frozen-thawed embryo transfer in patients with thin endometrium

作　　者：葛丽娜 张丽 闫蒙 GE Li’na;ZHANG Li;YAN Meng(Reproductive Medicine Center,Hebei Research Institute for Family Planning Reproductive Medicine Center Key Laboratory for Family Planning and HealthyHebei Key Laboratory of Reproductive Medicine,Hebei Province,Shijiazhuang 050071,China)

机构地区：[1]河北省计划生育科学技术研究院生殖医学中心,国家卫健委计划生育与优生重点实验室,河北省生殖医学重点实验室,河北石家庄050071

出　　处：《中国医药导报》2021年第24期88-91,共4页China Medical Herald

基　　金：河北省医学适用技术跟踪项目(G2019062)。

摘　　要：目的观察宫腔灌注人粒细胞集落刺激因子(G-CSF)对薄型子宫内膜冻融胚胎移植(FET)患者妊娠结局的影响。方法选择2017年12月至2019年12月河北省计划生育科学技术研究院行FET治疗的薄型子宫内膜不孕症患者100例为研究对象。根据患者本周期第1次就诊日的单、双日分为对照组(39例)和研究组(61例)。两组均采用激素替代周期,对照组宫腔灌注0.9%氯化钠注射液,研究组宫腔灌注G-CSF。比较两组宫腔灌注前后子宫内膜厚度、血流指数、子宫内膜形态、血流分型,观察两组妊娠结局。结果宫腔灌注后,研究组内膜厚度高于对照组,子宫动脉搏动指数低于对照组,差异有统计学意义(P<0.05);而两组阻力指数与收缩期峰值流速/舒张末期流速值比较,差异无统计学意义(P>0.05)。两组宫腔灌注前后子宫内膜形态比较,差异无统计学意义(P>0.05)。宫腔灌注后,两组子宫内膜下血流分型比较,差异有统计学意义(P<0.05)。两组周期取消率比较,差异无统计学意义(P>0.05);研究组临床妊娠率和着床率高于对照组,差异有统计学意义(P<0.05)。结论宫腔灌注G-CSF能够增加薄型子宫内膜厚度,改善薄型子宫内膜患者FET结局。Objective To observe the effect of intrauterine perfusion of human granulocyte colony stimulating factor(G-CSF)on outcome of frozen-thawed embryo transfer(FET)in patients with thin endometrium.Methods A total of 100 patients with thin endometrium infertility who underwent FET in Hebei Research Institute for Family Planning from December 2017 to December 2019 were selected as study objects.They were divided into control group(39 cases)and study group(61 cases)according to the odd and even days of the first visit day in this cycle.Both groups were treated with hormone replacement cycle.Control group was treated with 0.9% sodium chloride,and study group was intrauterine perfusion with G-CSF.Endometrial thickness,blood flow index,endometrial morphology,and blood flow typing before and after intrauterine perfusion were compared,and pregnancy outcome of two group were observed.Results After intrauterine perfusion,endometrial thickness in study group was higher than that in control group,and uterine artery pulsatility index was lower than that in control group,and the differences were statistically significant(P<0.05).There were no significant differences in resistance index and systolic peak velocity/end-diastolic velocity value between two groups(P>0.05).There was no significant difference in endometrial morphology between two groups before and after intrauterine perfusion(P>0.05).After intrauterine perfusion,the subendometrial blood flow typing of two groups was compared,and the difference was statistically significant(P<0.05).There was no significant difference in the period cancellation rate between two groups(P>0.05).The clinical pregnancy rate and implantation rate of study group were higher than those of control group,and the differences were statistically significant(P<0.05).Conclusion Intrauterine infusion of G-CSF can increase the thickness of thin endometrium and improve the outcome of FET in patients with thin endometrium.

关 键 词：人粒细胞集落刺激因子 冻融胚胎移植 薄型子宫内膜 宫腔灌注 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]