HIV感染女性宫颈癌筛查结果分析  

Analysis of cervical cancer screening results in HIV-infected women

作　　者：付丽华[1] 李慢[2] 伊诺[1] FU Lihua;LI Man;YI Nuo(Department of Obstetrics and Gynecology,Beijing Ditan Hosptal,Capital Medical University,Beijing 100015,China;Department of Pathology,Beijing Ditan Hosptal,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院妇产科,北京100015 [2]首都医科大学附属北京地坛医院病理科,北京100015

出　　处：《中国医药导报》2021年第24期99-102,共4页China Medical Herald

基　　金：吴阶平医学基金会遗传与优生专项基金(320.6750.17035)。

摘　　要：目的分析人类免疫缺陷病毒(HIV)感染女性宫颈癌筛查结果,为预防并管理HIV感染女性宫颈病变的发生提供依据。方法选取2018年1月至2020年10月首都医科大学附属北京地坛医院妇产科门诊的子宫颈液基薄层细胞学检查(TCT)及人乳头瘤病毒(HPV)的检查资料,其中HIV阳性女性137例为研究组,HIV阴性女性2891例为对照组。分析两组异常TCT和HPV亚型的分布情况。结果研究组高危型HPV阳性、低危型HPV阳性及多重感染阳性检出率高于对照组。研究组HPV分型以52、16、18、53型为多见;对照组HPV分型以52、16、58、18型为多见。研究组异常TCT为29例,占21.16%;对照组异常TCT为220例,占7.61%。结论HIV阳性女性子宫颈HPV阳性检出率高于HIV阴性女性,宫颈病变的发生概率高于HIV阴性女性。HIV感染女性应作为宫颈癌高危人群,缩短筛查时间。Objective To analyze the screening results of cervical cancer in women infected with human immunodeficiency virus(HIV),and to provide evidence for the prevention and management of cervical lesions in women infected with HIV.Methods Cervical thinprep cytologic test(TCT)and human papilloma virus(HPV)inspection data from Department of Obstetrics and Gynecology,Beijing Ditan Hospital,Capital Medical University were selected from January 2018 to October 2020.A total of 137 HIV positive women were in study group and 2891 HIV negative women were in control group.Abnormal TCT and distribution of HPV subtypes in two groups were analyzed.Results The positive rate of high-risk HPV,low-risk HPV and multiple infection in study group were higher than those in control group.In study group,type 52,16,18,53 were the most common HPV types;and in control group,type 52,16,58 and 18 were more common HPV types.In study group,29 cases(21.16%)were abnormal TCT;and in control group,abnormal TCT was 220 cases(7.61%).Conclusion The cervical HPV positive detection rate of HIV positive women is higher than that of HIV negative women,and the incidence of cervical lesions is higher than that of HIV negative women.Women infected with HIV should be considered at high risk of cervical cancer and the screening time should be shortened.

关 键 词：人类免疫缺陷病毒 人乳头瘤病毒 宫颈癌 

分 类 号：R512.91[医药卫生—内科学]