吡喹酮治疗门诊华支睾吸虫病患者的疗效观察  

Observation on the therapeutic effect of praziquantel in outpatients with Clonorchis Sinensis

作　　者：黄星炯 张国汉 梁美群 黄显泽 黄雅铃 危国强 HUANG Xing-jiong;ZHANG Guo-han;LIANG Mei-qun;HUANG Xian-ze;HUANG Ya-ling;WEI Guo-qiang(Center for Disease Prevention and Control of Wuming District,Nanning 530199,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]武鸣区疾病预防控制中心,广西南宁530199

出　　处：《热带病与寄生虫学》2021年第4期224-226,共3页Journal of Tropical Diseases and Parasitology

基　　金：广西卫生健康委自筹科研项目(Z20201471);南宁市武鸣区科技计划项目(20200218)。

摘　　要：目的探讨使用吡喹酮治疗门诊华支睾吸虫病患者临床疗效,为门诊常规驱虫治疗提供依据。方法选取2018年1月-2020年12月在南宁市武鸣区寄生虫病防治门诊就诊的2241例华支睾吸虫病患者为观察对象,给予吡喹酮总剂量7200 mg分3日9剂次服用驱虫治疗,同时服用消炎利胆片、护肝片、维生素B6等辅助药物,观察并分析治疗效果与不良反应。结果治疗后华支睾吸虫病患者粪检虫卵减少率为100.00%(2241/2241),虫卵总阴转率为98.93%(2217/2241),其中轻度、中度、重度感染者阴转率分别为99.30%(2124/2139)、91.92%(91/99)和66.67%(2/3),轻度与中度感染者粪检虫卵阴转率差异有统计学意义(χ^(2)=50.660,P=0.001)。粪检虫卵未阴转的患者再次服药治疗后,均未查到华支睾吸虫虫卵。药物不良反应发生率为9.15%,以神经系统症状为主,消化系统次之,症状较轻,未见严重不良反应。结论在华支睾吸虫病流行地区医疗卫生机构门诊,使用中剂量吡喹酮抗华支睾吸虫治疗,疗效好,药物不良反应少。Objective To explore the clinical efficacy of praziquantel in the treatment of outpatients with clonorchiasis for evidence in routine deworming regimen on outpatient basis.Methods 2241 patients with clonorchiasis treated in the clinic of Parasitic Disease Prevention of Wuming District were included from January 2018 to December 2020.The treatment regimen consisted of a total dosage of 7200 mg praziquantel orally used in 9 doses over 3 days,together with cholagogic tablets,liver-protecting tablets and vitamin B6 pills as well as other adjuvant drugs.Then the therapeutic effects and side effects were observed and analyzed.Results The reduction rate of eggs was 100.00%(2241/2241)in fecal examination of patients infected with Clonorchis Sinensis.The total negative conversion rate for the eggs was 98.93%(2217/2241),and 99.30%(2124/2139),91.92%(91/99)and 66.67%(2/3)for patients with mild,moderate and severe infection,respectively.There was significant difference in the negative egg conversion rate in patients with moderate and severe infection(χ^(2)=50.660,P=0.001).Clonorchis Sinensis eggs were not detected in the feces in patients with failed negative conversion medicated with added dose as previous regimen.The incidence of adverse drug reactions was 9.15%,with nervous system being dominant,followed by digestive system.The symptoms were generally mild,and no serious adverse response occurred.Conclusion Medium-dose praziquantel can be effective,yet lower side effects in the treatment of patients on outpatient clinic basis in areas with Clonorchis sinensis endemic.

关 键 词：华支睾吸虫病 吡喹酮 门诊治疗 疗效 

分 类 号：R532.23[医药卫生—内科学]