Ultrasound-Assisted Low-Density Solvent Dispersive Liquid-Liquid Extraction for the Determination of Amphetamines in Biological Samples Using Gas Chromatography-Mass Spectrometry  

作　　者：Liang Meng Wenwen Zhang Pinjia Meng Yuxian Liu 

机构地区：[1]Department of Forensic Science,Fujian Police College,Fuzhou 350007 [2]Traffic Management Bureau,Beijing Municipal Public Security Bureau,Beijing 100037 [3]College of Forensic Science,People's Public Security University of China,Beijing 100038 [4]Legal Affairs Section,Hunan Provincial Public Security Department,Changsha 410001,PR China

出　　处：《Journal of Forensic Science and Medicine》2015年第2期114-118,共5页法庭科学与法医学杂志（英文）

基　　金：supported by Technology Project of Education Department in Fujian:A(JA14336).

摘　　要：In order to control drug crime effectively,it is necessary to develop selective analytical methods suitable for unambiguous identification and determination of drugs in illicit samples and biological matrices.A novel microextraction technique based on ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction,(UA-LDS-DLLME)has been applied to the determination of four amphetamines(methamphetamine,amphetamine,3,4-methylenedioxymethamphetamine,and 3,4-methylenedioxyamphetamine)in urine samples by gas chromatography-mass spectrometry.The parameters affecting extraction efficiency have been investigated and optimized.UA-LDS-DLLME used ultrasound energy to assist in the emulsification process without any disperser solvent.Under the optimized conditions,linearity was observed for all analytes in the 0.15-10 p,g/mL range with correlation coefficients(R)ranging from 0.9886 to 0.9894.The recoveries of75.6-91.4%with relative standard deviations of 2.5-4.0%were obtained.The limits of detection(S/N=3)were estimated to be in the 5-10 ng/mL range.The UA-LDS-DLLME technique had the advantages of shorter extraction time,suitability for simultaneous pretreatments of batches of samples,and the higher extraction efficiency.It was successfully applied to the analysis of amphetamines in real human urine samples.

关 键 词：AMPHETAMINES biological samples dispersive liquid-liquid microextraction gas chromatography-mass spectrometry ultrasonication 

分 类 号：O62[理学—有机化学]