健脾化痰中药干预治疗慢性萎缩性胃炎的效果及对HSP70表达水平的影响  

Effect of Jianpi Huatan traditional Chinese medicine intervention in the treatment of chronic atrophic gastritis and its influence on HSP70 expression level

作　　者：汪楠[1] 李岩[2] 高雪 WANG Nan;LI Yan;GAO Xue(GCP Office(Phase One Clinical Trial Ward),Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110032,China;Department of Spleen and Stomach,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110032,China)

机构地区：[1]辽宁中医药大学附属医院GCP办公室(一期临床试验病房),辽宁沈阳110032 [2]辽宁中医药大学附属医院脾胃病科,辽宁沈阳110032

出　　处：《中国医药导报》2021年第22期149-152,共4页China Medical Herald

基　　金：辽宁省自然基金指导计划项目(2019-ZD-0960)。

摘　　要：目的探究健脾化痰中药干预治疗慢性萎缩性胃炎的效果及对热休克蛋白70(HSP70)表达水平的影响。方法选取辽宁中医药大学附属医院2018年4月至2020年4月收治的慢性萎缩性胃炎患者120例,采取随机数字表法分为常规组与联合组,各60例。常规组给予西药治疗,联合组在常规组的基础上加用健脾化痰中药干预治疗。比较两组临床总体疗效、胃黏膜腺体萎缩疗效、治疗前后中医证候积分及胃黏膜匀浆HSP70扫描峰面积。结果联合组临床总有效率高于常规组,差异有统计学意义(P<0.05)。联合组胃黏膜腺体萎缩总有效率高于常规组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分均低于治疗前,且联合组低于常规组,差异有统计学意义(P<0.05)。治疗后,两组胃黏膜匀浆HSP70扫描峰面积均大于治疗前,且联合组大于常规组,差异有统计学意义(P<0.05)。结论健脾化痰中药干预治疗慢性萎缩性胃炎可有效改善相关临床症状,促进胃黏膜腺体萎缩,调节HSP70的表达水平。Objective To explore the effect of Jianpi Huatan traditional Chinese medicine intervention in the treatment of chronic atrophic gastritis and its influence on HSP70 expression level.Methods One hundred and twenty patients with chronic atrophic gastritis in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from April 2018 to April 2020 were selected and divided into conventional group and combined group according to random number table method,with 60 cases in each group.Conventional group was treated with Western medicine,and combined group was treated with Jianpi Huatan traditional Chinese medicine on the basis of conventional group.The overall clinical efficacy,the efficacy of gastric mucosal gland atrophy,traditional Chinese medicine syndrome score and the scanning peak area of HSP70 in gastric mucosa homogenate before and after treatment were compared between two groups.Results Total clinical effective rate of combined group was higher than that of conventional group,and the difference was statistically significant(P<0.05).The effect of gastric mucosal gland atrophy in combined group was higher than that in conventional group,and the difference was statistically significant(P<0.05).After treatment,traditional Chinese medicine syndrome scores of two groups were lower than those before treatment,and combined group was lower than conventional group,and the differences were statistically significant(P<0.05).After treatment,the scanning peak area of HSP70 in gastric mucosa homogenate of two groups was larger than that before treatment,and combined group was larger than that conventional group,and the differences were statistically significant(P<0.05).Conclusion Jianpi Huatan traditional Chinese medicine intervention in the treatment of chronic atrophic gastritis can effectively improve the related clinical symptoms,promote the atrophy of gastric mucosal glands,and regulate the expression level of HSP70.

关 键 词：健脾化痰 慢性萎缩性胃炎 疗效 热休克蛋白70 

分 类 号：R256.3[医药卫生—中医内科学]