CHB患儿干扰素α1b长期给药后血清β2-微球蛋白浓度的影响因素分析  

Influencing factors analysis of β2-microglobulin concentration after long-term interferon α1b administration in children with CHB

作　　者：柴燕涛 王福川 侯俊 贾凡 刘佳 姜棋予 张敏 毕京峰 CHAI Yantao;WANG Fuchuan;HOU Jun;JIA Fan;LIU Jia;JIANG Qiyu;ZHANG Min;BI Jingfeng(Department of Infectious Diseases Medicine,the Fifth Medical Center of General Hospital of Chinese People’s Liberation Army,Beijing100039,China;Department of Hepatology Diseases,the Fifth Medical Center of General Hospital of Chinese People’s Liberation Army,Beijing100039,China;Clinical Testing Center,the Fifth Medical Center of General Hospital of Chinese People’s Liberation Army,Beijing100039,China;Clinical Blood Transfusion Center,the Fifth Medical Center of General Hospital of Chinese People’s Liberation Army,Beijing100039,China)

机构地区：[1]中国人民解放军总医院第五医学中心感染病医学部,北京100039 [2]中国人民解放军总医院第五医学中心肝病医学部,北京100039 [3]中国人民解放军总医院第五医学中心临床检验中心,北京100039 [4]中国人民解放军总医院第五医学中心临床输血科,北京100039

出　　处：《中国医药导报》2021年第23期60-63,79,共5页China Medical Herald

基　　金：首都卫生发展科研专项项目(首发2018-2-5035)。

摘　　要：目的探索慢性乙型肝炎(CHB)患儿干扰素长期给药后血清β2-微球蛋白浓度的相关影响因素。方法收集2017年12月至2019年9月于中国人民解放军总医院第五医学中心就诊的108例CHB患儿长期应用干扰素α1b后的血清标本。应用多重线性回归分析方法,以血清β2-微球蛋白浓度为因变量,以性别、年龄、体重指数(BMI)、疗程、给药时间(采样时间与采样前最后1次用药的间隔时间)、给药剂量、病毒基因分型等信息为自变量,分析血清β2-微球蛋白浓度的相关影响因素。结果β2微球蛋白与年龄、疗程、给药时间及BMI无相关性(P>0.05)。不同性别、乙型病毒性肝炎基因型、给药剂量β2微球蛋白比较,差异无统计学意义(P>0.05)。给药剂量、年龄、给药时间、疗程是影响血清β2微球蛋白浓度的相关因素(P<0.05),其中血清β2微球蛋白浓度伴随给药剂量的升高而升高,伴随年龄、给药时间及疗程的增大而降低。结论血清β2-微球蛋白的浓度不仅仅与给药剂量有关联,给药时间、疗程及年龄也对血清β2微球蛋白浓度具有一定的影响。Objective To explore the related factors of serumβ2-microglobulin concentration after long-term administration of interferon in children with chronic hepatitis B(CHB).Methods Serum samples of 108 children with CHB who were treated at the Fifth Medical Center of People’s Liberation Army General Hospital from December 2017 to September 2019 were collected after long-term interferonα1b application.Multiple linear regression analysis method was used,with serumβ2-microglobulin concentration as the dependent variable,taking gender,age,body mass index(BMI),course of treatment,administration time(the interval between sampling time and the last medication before sampling),administration dose,virus genotyping and other information as independent variables,the related influencing factors of serumβ2-microglobulin concentration were analyzed.Results There was no correlation betweenβ2-microglobulin and age,course of treatment,time of administration and BMI(P>0.05).There were no statistically significant differences in different genders,viral hepatitis type B genotypes,and doses ofβ2-microglobulin(P>0.05).Dosage,age,time of administration,and course of treatment are related factors that affect the concentration of serumβ2-microglobulin(P<0.05),among them,the serumβ2-microglobulin concentration increases with the increase of the dose,and decreases with the increase of age,administration time and treatment course.Conclusion The concentration of serumβ2-microglobulin is not only related to the dose,but the time,duration of treatment and age also have certain effects on the concentration of serumβ2-microglobulin.

关 键 词：儿童 慢性乙型肝炎 干扰素 Β2-微球蛋白 

分 类 号：R5[医药卫生—内科学]