体积骨密度评价骨质疏松症的价值和前景  

The value and prospect of vBMD in the evaluation of osteoporosis

作　　者：孙蕾[1] 李晓丹 张月华 徐健[1] 王文志[1] 杨定焯[1] SUN Lei;LI Xiaodan;ZHANG Yuehua;XU Jian;WANG Wenzhi;YANG Dingzhuo(Department of Osteoporosis,No 4 West China Teaching Hospital,Sichuan University,Chengdu 610041;Department of Digestive Internal,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西第四医院骨质疏松科,四川成都610041 [2]四川大学华西医院消化科,四川成都610041

出　　处：《中国骨质疏松杂志》2021年第8期1227-1231,共5页Chinese Journal of Osteoporosis

基　　金：四川省科技厅重点项目(2018SZ0396)。

摘　　要：20多年来面积骨密度(areal bone mineral density,aBMD)在骨质疏松症(osteoporosis,OP)的临床和科研中发挥了重要作用,但是骨矿含量(bone mineral content,BMC)的不完全标准化及与骨生物力学负荷原则的不适应,导致漏、误诊增多。因此,骨生物力学研究中提出了更好的表观密度(体积骨密度-volumetric bone mineral density,vBMD)指标,vBMD是适合骨生物力学要求的形态学指标,可能是获得活体骨强度的过渡指标。vBMD排除了个体骨大小不同对骨量的影响,增强了个体间的可比性。vBMD在临床应用上拓宽了正常参考值的应用范围(儿童和成人共用),提高了诊断OP的准确性(避免了BMD指标引起的漏、误诊)。vBMD具有多种优越性,是值得进一步开发的中线骨骨质疏松诊断指标。Over the past 20 years,the area bone mineral density(aBMD)has played an important role in the clinical and scientific research of osteoporosis(OP).However,the incompletely standardization of bone mineral content(BMC)and its inadaptability to the principle in bone biomechanics lead to the increasely rate of misdiagnosis or missed diagnosis.Therefore,volumetric bone mineral density(vBMD)which is a better index of bone biomechanics,has been put forward.vBMD is a morphological index to bone biomechanics,which may be a transitional index to obtain bone strength in vivo.In addition,vBMD can exclude the influence of different bone size on bone mass and enhance the comparability between individuals.In clinical application,vBMD widens the application range of normal reference value(shared by children and adults),and improves the accuracy of OP diagnosis.vBMD has many advantages,and it is worth further developing.

关 键 词：骨质疏松 骨矿含量 标准化 体积骨密度 

分 类 号：R580[医药卫生—内分泌]