分化型甲状腺癌研究的主题挖掘及引文科学的知识域可视化  

Exploration of research topics and visualization of knowledge domain of citation science on differentiated thyroid cancer

作　　者：王权 杨珂璐 李杨[1] 刘明[2] 杨晓东[1] 叶颖江[1] 姜可伟[1] Wang Quan;Yang Kelu;Li Yang;Liu Ming;Yang Xiaodong;Ye Yingjiang;Jiang Kewei(Department of Gastroenterological Surgery,Laboratory of Surgical Oncology,Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research,Peking University People’s Hospital,Peking 100044,China;Evidence-Based Medicine Center of Lanzhou University,Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]北京大学人民医院胃肠外科,北京大学人民医院外科肿瘤研究室,北京市结直肠癌诊疗研究重点实验室,100044 [2]兰州大学循证医学中心,甘肃省循证医学与临床转化重点实验室,735000

出　　处：《中华内分泌外科杂志》2021年第4期387-393,共7页Chinese Journal of Endocrine Surgery

基　　金：科学中心项目(62088101)。

摘　　要：目的构建分化型甲状腺癌(differentiated thyroid cancer,DTC)研究的主题挖掘和引文科学的知识域可视化图谱,概括核心研究主题并分析引文情况,为后续的研究提供参考。方法在Web of Science数据库中检索DTC相关文献。检索时间为建库至2021年4月4日,纳入已发表DTC的相关文献,采用VOSviewer 1.6.11与CiteSpace 5.5.R2软件对纳入文献的研究主题的聚类及时序分析,并构建共被引文献知识域的可视化图谱。结果共纳入8629篇DTC文献,包含87973篇引文。年发文量均逐年递增,尤其在2005年后,年递增趋势更加显著。临床分期和外科手术管理及靶向治疗的临床研究是当前热点主题。引文分析可知,115篇引文的共被引次数超过100次,14篇的被引次数超过300次,2篇的引用次数超过1000次。发文量top15的发表年份区间为1988~2016年,发现2006年前DTC的研究发展相对缓慢;而2006年后4篇高被引文献的发表,DTC的年发文量明显增加;且2014~2016年,3篇高被引文献相继发表。引用次数超过1000次的引文发表在Thyroid杂志上,且为ATA发布的DTC指南共识;与此同时,DTC的靶向治疗及放射性131I治疗等方面均有高被引文献的出现,而DTC外科手术治疗缺乏新的高被引文献。结论已发表DTC文献的当前热点主题集中在临床分期、外科手术管理及靶向治疗等方面;同时,高质量的临床指南、靶向药物的随机对照试验对DTC的研究影响巨大,未来研究应更多关注复发/转移性DTC。Objective To summarize the core research topics of the literature on differentiated thyroid cancer(DTC),and to analyze the citation status to form the knowledge domain of citation science.Methods Web of Science was used to search the literature on DTC,which was limited to April 04,2021.The published records on DTC were identified.VOSviewer 1.6.11 and CiteSpace 5.5.R2 software were used to cluster and visualize the knowledge domain of citation.Results A total of 8,629 records on DTC were obtained,including 87,973 citations,which showed that the publication volume increased year by year.Moreover,the trend of the annual records became more significant after the year of 2005.Meanwhile,it was reported that clinical staging and surgical management,as well as clinical researches on targeted therapy drugs,were treated as the currently hot research topics.The data showed that 115 records were cited more than 100 times,and 14 cited more than 300 times.And two records had been cited more than 1,000 times.Furthermore,the publication year of top15 were from 1988 to 2016,which also illustrated that the development of DTC researches were relatively slow before 2006.And the annual publication volume of DTC increased significantly with the publication of four highly cited records in 2006,even three with which have 1,000 citations.And the results revealed that the Consensus and Clinical Guidelines on DTC issued by ATA,as well as targeted therapy and radioactive 131I therapy on DTC had been highly cited.However,the newer highly cited documents on surgical treatment of DTC were still lacking.Conclusions The current hot topics on DTC are focused on clinical staging,surgical management and targeted therapy.And a high-quality clinical guidelines and consensus and RCTs of targeted drugs on DTC have a significant impact on its development.Moreover,the further researches need to pay more attention to persistent/recurrent and metastatic DTC.

关 键 词：分化型甲状腺癌 主题挖掘 知识域可视化 热点 证据 

分 类 号：R653[医药卫生—外科学] R736.1[医药卫生—临床医学]