不同免疫状态下启动抗病毒治疗对HIV/AIDS免疫重建情况的分析  

Analysis of immune reconstitution of HIV/AIDS by initiating antiviral therapy under different immune states

作　　者：付士武 王桂侠 FU Shi-wu;WANG Gui-xia(Daxing District Lixian Town Central Health Center,Beijing 102604,China)

机构地区：[1]北京市大兴区礼贤镇中心卫生院,北京102604

出　　处：《中国卫生检验杂志》2021年第15期1903-1905,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的比较不同免疫状态下开始抗病毒治疗对艾滋病病毒感染者/患者(HIV/AIDS)免疫重建的影响。方法对在北京市大兴区接受医学随访且接受抗病毒治疗>1年,年龄≥18岁,有初始治疗CD4淋巴细胞数值的HIV/AIDS,按照基线CD4淋巴细胞计数分成4组:CD4≥500个/mm^(3)、CD4350个/mm^(3)~499个/mm^(3)、CD4200个/mm^(3)~349个/mm^(3)、CD4<200个/mm^(3),比较这4组HIV/AIDS治疗满1年后CD4淋巴细胞数值变化及病毒载量抑制的情况。结果4组研究对象共711例,其性别分布、年龄分布、文化程度差异均无统计学意义(P>0.05)。4组研究对象治疗后CD4淋巴细胞计数均值较基线升高(F=23.656,P<0.05)。CD4≥500个/mm^(3)组在抗病毒治疗后6个月、12个月、18个月、24个月CD4淋巴细胞计数均值均明显高于其他组。在治疗满1年后,4组病毒载量抑制比例差异有统计学意义(P<0.05)。结论早期抗病毒治疗可以保持较高的免疫水平,有利于HIV/AIDS免疫功能恢复,同时病毒载量抑制率高。Objective To compare the effects of starting antiviral therapy in different immune states on immune reconstitution in HIV/AIDS patients.Methods The patients with HIV/AIDS who were≥18 years old,received medical follow-up and antivi⁃ral therapy in Daxing District of Beijing for more than 1 year,and had initial treatment CD4 lymphocyte value.According to the baseline CD4 lymphocyte count,they were divided into 4 groups:CD4≥500 cell/mm^(3),CD4350 cell/mm^(3)-499 cell/mm^(3),CD4200 cell/mm^(3)-349 cell/mm^(3),and CD4<200 cell/mm^(3).The changes of CD4 lymphocyte value and viral load inhibition in these 4 groups were compared after 1 year of HIV/AIDS treatment.Results There were 711 subjects in the 4 groups,and there was no statistical significance on the differences in gender distribution,age distribution and education level(P>0.05).The mean CD4 lymphocyte count in the 4 groups increased after treatment compared with the baseline(F=23.656,P<0.05).The mean counts of CD4 lymphocytes in the group of CD4≥500 cell/mm^(3) at 6,12,18 and 24 months after antiviral therapy were significantly higher than those in the other groups.After 1 year of treatment,there was statistical significance on the differ⁃ence in the proportion of viral load inhibition among the 4 groups(P<0.05).Conclusion Early antiviral therapy can main⁃tain a high level of immunity,which is conducive to the recovery of HIV/AIDS immune function,and the disease load inhibition rate is high.

关 键 词：抗病毒治疗 艾滋病病毒感染者/患者 病毒载量 

分 类 号：R512.91[医药卫生—内科学]