阻断乙型肝炎病毒母婴传播的相关研究进展  

Advances in the prevention of mother-to-child transmission of hepatitis B virus

作　　者：顾桂芳 秦刚[2] 俞冲[3] 崔爱民[4] 姚微[1] 张玉泉[1] Gu Guifang;Qin Gang;Yu Chong;Cui Aimin;Yao Wei;Zhang Yuquan(Department of Obstetrics and Gynecology,Affiliated Hospital of Nantong University,Nantong 226001,China;Department of Infectious Diseases,Nantong Third People's Hospital,Nantong University,Nantong 226006,China;Branch of Liver Diseases,Nantong Third People's Hospital,Nantong University,Nantong 226006,China;Department of Obstetrics,Nantong Maternal and Child Health Hospital,Nantong 226008,China)

机构地区：[1]南通大学附属医院妇产科,226001 [2]南通大学附属南通第三医院感染科,226006 [3]南通大学附属南通第三医院肝病科,226006 [4]南通市妇幼保健院产科,226018

出　　处：《中华围产医学杂志》2021年第8期597-600,共4页Chinese Journal of Perinatal Medicine

摘　　要：乙型肝炎(简称乙肝)病毒母婴传播是乙肝主要传播途径。母婴传播主要见于高病毒载量和乙肝e抗原阳性的孕妇。对这些孕妇孕晚期给予抗病毒治疗,联合新生儿和婴儿及时规范全程接种乙肝免疫球蛋白和乙肝疫苗,以尽最大可能阻断母婴传播。本文对孕期抗病毒药物用药、停药和产后乙肝发作处理、母乳喂养问题进行综述,以进一步优化联合免疫接种和抗病毒治疗策略,寻求阻断母婴传播的最佳方案。Mother-to-child transmission(MTCT)of hepatitis B virus(HBV)represents the most common mode by which children acquire HBV infection.For pregnant women with high viral load and positive hepatitis B e antigen(HBeAg),antiviral therapy during late pregnancy combined with timely and standardized inoculation of neonatal hepatitis B immunoglobulin and hepatitis B vaccine can minimize the possibility of MTCT of HBV.This review focuses on using and withdrawing antiviral drugs during pregnancy,managing postpartum hepatitis,and breastfeeding issues to further optimize the combined immunization and antiviral treatment strategies and seek the optimal solution to preventing MTCT of HBV.

关 键 词：乙型肝炎病毒 母婴传播 免疫接种 抗病毒治疗 防治措施 

分 类 号：R714.251[医药卫生—妇产科学]