复方氯唑沙宗对胸腰椎骨折老年患者保守治疗的临床研究  

Effect of compound chlorzoxazone on conservative treatment of elderly patients with thoracolumbar fractures

作　　者：汪颖峰[1] 俞胜宝[1] 罗俊杰[1] 周建 李毅 黄定安[1] WANG Ying-feng;YU Sheng-bao;LUO Jun-jie;ZHOU Jian;LI Yi;HUANG Ding-an(Department of Spine Surgery,Huangshan People’s Hospital,Huangshan 245000,Anhui Province,China)

机构地区：[1]黄山市人民医院脊柱外科,安徽黄山245000

出　　处：《中国临床药理学杂志》2021年第16期2128-2131,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察复方氯唑沙宗对胸腰椎骨折老年患者保守治疗的效果。方法将72例患者依据随机数字的方法分为对照组36例与试验组36例。对照组给予常规药物治疗;试验组在对照组的基础上给予复方氯唑沙宗分散片,每次550 mg,每日3次,口服,入院后连续服用10 d停药,受伤后3个月开始护具保护下康复练习,连续口服10 d停药。2组的治疗时间均设定为椎体受伤后4个月。比较2组患者的疼痛情况指标[视觉模拟评分(VAS)]、影像学指标[椎体压缩率、Cobb角]、骨密度指标[T值、Z值、骨密度(BMD)]、脊椎功能指标[Oswestry功能障碍指数(ODI)]、临床疗效和药物不良反应发生情况。结果试验组和对照组的总有效率分别为100.00%和83.33%,差异有统计学意义(P<0.05)。治疗后10 d,试验组和对照组的VAS分别为(1.67±0.50)和(2.48±0.78)分,椎体压缩率分别为(4.39±1.21)%和(7.15±3.27)%,Cobb角分别为(5.35±1.83)°和(7.02±2.25)°,ODI评分分别为(18.35±4.36)和(23.28±5.21)分,差异均有统计学意义(均P<0.05)。治疗后4个月,试验组和对照组的VAS评分分别为(0.51±0.18)和(0.72±0.24)分,差异有统计学意义(均P<0.05)。试验组和对照组的药物不良反应发生率分别为13.89%和11.11%,差异无统计学意义(P>0.05)。结论采用保守治疗的胸腰椎骨折老年患者,在住院期间和下床恢复时期内给予复方氯唑沙宗,可改善镇痛效果,提升疗效,促进恢复,具有可靠的安全性。Objective To observe the effect of compound chlorzoxazone on conservative treatment of elderly patients with thoracolumbar fractures. Methods According to the random number method, 72 patients were divided into control group of 36 cases and treatment group of 36 cases. The control group was given conventional medication;on the basis of control group, treatment group was given compound chlorzoxazone dispersible tablets, 550 mg each time, 3 times a day, orally, after admission to the hospital, the drug was stopped after 10 consecutive days, and rehabilitation exercises under the protection of protective gear started 3 months after the injury, continuous oral administration compound chlorzoxazone dispersible tablets for 10 days and stopped. The treatment time for both groups was set to 4 months after vertebral body injury. The pain indicators of the two groups [visual analog scale ( VAS) ],imaging indicators [vertebral body compression ratio,Cobb angle],bone mineral density [T value,Z value,bone density( BMD) ],spine function indicators [Oswestry dysfunction index( ODI) ],clinical effect,adverse drug reactions in two groups were compared. Results The total effective rates of treatment group and control group were 100. 00% and 83. 33%,the difference was statistically significant( P < 0. 05). On 10 days after treatment,the VAS of treatment group and control group were 1. 67 ± 0. 50 and 2. 48 ± 0. 78,the vertebral compression rates were( 4. 39 ± 1. 21) % and( 7. 15 ± 3. 27) %,the Cobb angles were( 5. 35 ± 1. 83) ° and( 7. 02 ± 2. 25) °,the ODI scores were 18. 35 ± 4. 36 and 23. 28 ± 5. 21,the difference was statistically significant( all P < 0. 05). After 4 months treatment,the VAS of treatment group and control group were 0. 51 ± 0. 18 and 0. 72 ± 0. 24,the difference was statistically significant( P < 0. 05). The incidence of adverse drug reactions in treatment group and control group were13. 89% and 11. 11%,the difference was not statistically significant( P > 0. 05). Conclusion For elderly patients with

关 键 词：复方氯唑沙宗 胸腰椎骨折 老年患者 保守治疗 骨密度 

分 类 号：R97[医药卫生—药品]