Sec信号通路调控真核生物蛋白质转运机制的研究进展  

Advances in Sec Pathway Regulating Protein Transport Mechanism in Eukaryotes

作　　者：陈娇 郭龙 李飞 李发弟[1,2] CHEN Jiao;GUO Long;LI Fei;LI Fa-Di(State Key Laboratory of Grassland Agro-ecosystem,Lanzhou 730020,China;College of Pastoral Agriculture Science and Technology,Lanzhou University,Lanzhou 730020,China)

机构地区：[1]草地农业生态系统国家重点实验室,兰州730020 [2]兰州大学草地农业科技学院,兰州730020

出　　处：《农业生物技术学报》2021年第8期1604-1611,共8页Journal of Agricultural Biotechnology

基　　金：甘肃省科技计划项目(20JR10RA642);兰州大学引进人才科研启动费(561119219)。

摘　　要：一般分泌信号通路(general secreation pathway,Sec)是调控蛋白质运输和分泌的重要途径,广泛存在于各类型细胞之中。Sec受胞内ATP合酶的刺激活化,进而促进酶蛋白的跨膜转运,可提高反刍动物胰腺消化酶的分泌。本文以信号网络为核心,综述了Sec途径调控蛋白质转运机理以及营养素氨基酸对哺乳动物胰腺腺泡细胞蛋白质分泌调控的机制,为揭示细胞分泌蛋白的调控原理及利用营养手段改善反刍动物的胰腺消化酶的分泌能力提供理论基础。The general secretion pathway(Sec)is an essential pathway to regulate protein transport and widely exists in various types of cells.The ATPase can stimulate the Sec pathway,which promotes the transmembrane transport of enzyme proteins,and increases the secretion of trypsin in ruminant's pancreas.Based on the signal network,this review describes the regulation factors of functional amino acid and the mechanism of protein transport through the Sec pathway,which provides a theoretical basis for the regulation principle of secretory cells and the improvement of animal digestion by nutritional means.

关 键 词：胰酶分泌 Sec信号通路 亮氨酸 共翻译易位 翻译后易位 膜屏障 

分 类 号：S811.3[农业科学—畜牧学]