中西医结合诊治肾虚血瘀型排卵障碍性不孕(不育)优势的探究  

Advantages of integrated Chinese and western medicine in diagnosis and treatment of anovulatory infertility due to kidney deficiency and blood stasis

作　　者：马堃[1] MA Kun(China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院,北京100700

出　　处：《中国中药杂志》2021年第11期2623-2628,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(81674019);首都临床特色应用研究项目(Z17110000107104)。

摘　　要：在"肾主生殖"理论指导下,阐述了肾虚血瘀证导致无排卵型异常子宫出血、多囊卵巢综合征、高催乳素血症、未破裂卵泡黄素化综合征、黄体功能不足、早发性卵巢功能不全6种排卵障碍性不孕的机制。系列研究证实其能提高卵巢对促性腺激素的反应性,改善卵巢功能[显著调节雌二醇(E2)、泌乳素(PRL)的作用,降低卵泡刺激素(FSH)、黄体生成素(LH)、孕激素(P),睾酮(T)];能够促进卵泡发育、排出和同步子宫内膜生长,而提高排卵率及妊娠成功率。中西医结合诊治肾虚血瘀型排卵障碍性不孕,以"病-证-症"的研究模式,突出"以证统病"的中医诊治思维模式和"辨病与辨证相结合"的特色优势,诠释了中医"异病同治"治疗原则。Under the guidance of the theory of "kidney governing reproduction", this study demonstrated the mechanism of six types of ovulatory infertility caused by kidney deficiency and blood stasis, including anovulatory bleeding, polycystic ovary syndrome, hyperprolactinemia, luteinized unruptured follicle syndrome, luteal phase deficiency, and primary ovarian insufficiency. A series of studies have confirmed that integrated Chinese and western medicine can increase the responsiveness of the ovaries to gonadotropins and improve ovarian function by regulating the effects of estradiol(E2), prolactin(PRL), and reducing follicle-stimulating hormone(FSH), luteinizing hormone(LH), progestin(P), and testosterone(T). It can also improve ovulation rate and pregnancy success rate by promoting follicle development, discharging, and synchronizing endometrial growth. This study illustrated the diagnosis and treatment of ovulatory infertility caused by kidney deficiency and blood stasis with integrated traditional Chinese and Western medicine in the "disease-syndrome-symptom" research mode, and highlighted the traditional Chinese medicine(TCM) idea of differentiating diseases based on syndromes and unique advantages of the combination of disease differentiation and syndrome differentiation, and interpreted TCM principle of "treating different diseases with the same method".

关 键 词：排卵障碍性不孕 中西医结合 肾虚血瘀 

分 类 号：R711.6[医药卫生—妇产科学]