芪龙祛瘀合剂对急性缺血性脑卒中(气虚血瘀型)患者血小板聚集功能及生存质量的影响  

Effects of Qilong Quyu decoction on platelet aggregation function and quality of life in patients with acute ischemic stroke(Qi deficiency and blood stasis syndrome)

作　　者：张红智[1] 张静思 房雷[1] 龚帆[1] 唐海燕[1] 王骏[1] 俞晓飞[1] ZHANG Hongzhi;ZHANG Jingsi;FANG Lei;GONG Fan;TANG Haiyan;WANG Jun;YU Xiaofei(Department of Encephalopathy,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院脑病科,上海201203

出　　处：《世界临床药物》2021年第7期557-564,共8页World Clinical Drug

基　　金：上海市卫健委卫生行业临床研究专项项目(201940212);上海市卫健委“杏林新星”计划人才培养项目(ZY3-RCPY-2-2073);专科(中医脑病科)培育项目[沪卫中管(2019)7号]。

摘　　要：目的探讨芪龙祛瘀合剂用于治疗急性缺血性脑卒中(气虚血瘀型)的有效性及安全性。方法选取2018年1月至2020年6月期间上海中医药大学附属曙光医院脑病科收治的急性缺血性脑卒中(气虚血瘀型)患者124例,按照随机数字表法随机分为试验组和对照组,每组62例。在西医常规治疗的基础上,试验组患者服用芪龙祛瘀合剂,对照组患者服用芪龙祛瘀合剂安慰剂。疗程28 d,随访90 d。两组在试验前、后进行血小板聚集功能、脑卒中中医症征积分及日常生活活动能力(Barthel指数)的比较。结果治疗28d后,两组患者的花生四炼酸(arachidonicacid,AA)、二隣酸腺苷(adenosine diphosphate,ADP)诱导血小板聚集率均有下降,试验组患者的AA及ADP诱导血小板聚集率均低于对照组(P<0.05或户<0.01);在治疗28 d后及90 d随访时,两组患者的脑卒中中医症征量表积分均有降低,Barthel指数均有提高。试验组患者的脑卒中中医症征量表积分低于对照组(户<0.05或P<0.01);试验组患者的Barthe丨指数高于对照组(P<0.01)。两组均未见明显不良反应。结论相对于西医常规治疗方案,芪龙祛瘀合剂中西医结合治疗方案能显著提升急性缺血性脑卒中患者的治疗效果,改善患者的生存质量,在临床中具有较好的应用价值。Objective To explore the efficacy and safety of Qilong Quyu decoction in the treatment of acute ischemic stroke(Qi deficiency and blood stasis syndrome).Methods A total of 124 acute ischemic stroke patients(Qi deficiency and blood stasis syndrome)admitted to the Department of Encephalopathy,Shuguang Hospital of Shanghai University of Traditional Chinese Medicine from January 2018 to June 2020,were randomly divided into treatment group and control group according to the random number table method,and 62 cases in each group.Based on the conventional western medicine,the patients in treatment group received Qilong Quyu Decoction,and the patients in control group received placebo of Qilong Quyu Decoction.The course of treatment was 28 days,following up 90 days.Before and after treatment,platelet aggregation function,score of stroke traditional Chinese medicine(TCM)symptom scale and Barthel index in the two groups were compared.Results After 28 days of treatment,the platelet aggregation rates induced by AA and ADP were decreased in both groups.The platelet aggregation rates induced by AA and ADP in treatment group were both lower than those in control group(P<0.05 or P<0.001).After 28 days of treatment and 90 days of follow-up,the score of the stroke TCM symptom scale was reduced,and the Barthel index was increased in both groups.The score of stroke TCM symptom scale in treatment group was lower than that in control group(P<0.05 or P<0.01).The Barthel index in treatment group was higher than that in control group(P<0.01).There were no obvious adverse reactions in both groups.Conclusion Compared with the conventional western medicine treatment,Qilong Quyu decoction combined with conventional western medicine treatment can significantly improve the treatment effect of patients with acute ischemic stroke,improve patients'quality of life,has good clinical application value.

关 键 词：芪龙祛瘀合剂 急性缺血性脑卒中 气虚血瘀型 血小板聚集功能 脑卒中中医症征积分量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]