裸花紫珠叶的化学成分研究  

Chemical Constituents of Callicarpa nudiflora Leaves

作　　者：杨建琼[1] 李亚梅 杨义芳[3,4] 吴彤 李小锋[5] 康兴东 杨扬 YANG Jian-qiong;LI Ya-mei;YANG Yi-fang;WU Tong;LI Xiao-feng;KANG Xing-dong;YANG Yang(Research Center,First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;College of Pharmacy,Gannan Medical University,Ganzhou 341000,China;Shanghai Institute of Pharmceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 201203,China;Shanghai Yaochen Biotechnology Co.,Ltd,Shanghai 200060,China;Jiangxi Puzheng Pharmaceutical Co.,Ltd,Ji’an 343100,China)

机构地区：[1]赣南医学院第一附属医院临床医学研究中心,江西赣州341000 [2]赣南医学院药学院,江西赣州341000 [3]中国医药工业研究总院上海医药工业研究院,上海201203 [4]上海药辰生物科技有限公司院,上海200060 [5]江西普正制药有限公司,江西吉安343100

出　　处：《中药材》2020年第7期1617-1621,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(31460082);国家中医药管理局科研基金项目(ZYBZH-C-JX-40)。

摘　　要：目的:研究裸花紫珠叶的化学成分。方法:运用反相制备色谱等方法对裸花紫珠叶的提取物进行分离纯化,根据理化性质及波谱数据对化合物结构进行鉴定。结果:从裸花紫珠叶中分离得到15个化合物,分别鉴定为:连翘酯苷E(1)、6″-O-trans-caffeoylcatalpol(2)、香叶木素(3)、3,7-二甲氧基-槲皮素(4)、syn-3,4-seco-12R-hydroxy-15,16-epoxy-4(18),8(17),13(16),14(15)-labdatetraen-3-oic acid(5)、(12E)-3,4-seco-labda-4(18),8(20),12,14-tetraen-3-oic acid 2(6)、梓醇(7)、芹菜素(8)、异鼠李素(9)、5,4′-二羟基-3,7,3′-三甲氧基黄酮(10)、原儿茶醛(11)、对羟基苯甲醛(12)、对羟基桂皮酸(13)、水杨酸(14)、木犀草素(15)。结论:其中,化合物1、3、4、6为首次从紫珠属植物中分离得到。Objective:To study the chemical constituents of Callicarpa nudiflora leaves.Methods:The compounds were isolated and purified by reversed phase preparative chromatography and their structures were identified according to their physical and chemical properties and spectral data.Results:Fifteen compounds were isolated from Callicarpa nudiflora leaves,and identified as forsythiaside E(1),6″-O-trans-caffeoylcatalpol(2),diosmetin(3),3,7-dimethoxy-quercetin(4),syn-3,4-seco-12R-hydroxy-15,16-epoxy-4(18),8(17),13(16),14(15)-labdatetraen-3-oic acid(5),(12E)-3,4-seco-labda-4(18),8(20),12,14-tetraen-3-oic acid 2(6),catalpol(7),apigenin(8),isorhamnetin(9),5,4′-dihydroxy-3,7,3′-trimethoxy flavone(10),protocatechuic aldehyde(11),p-hydroxy benzaldehyde(12),4-hydroxy cinnamic acid(13),salicylic acid(14),luteolin(15),respectively.Conclusion:Among them,compounds 1,3,4,6 are isolated from Callicarpa genus for the first time.

关 键 词：裸花紫珠 化学成分 分离纯化 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]