CRNDE靶向微RNA-212-5p基因对骨关节炎软骨细胞增殖、凋亡及炎症因子分泌的影响  

CRNDE regulates proliferation and apoptosis of chondrocytes and secretion of inflammatory factors in osteoarthritis via targeting miR-212-5p

作　　者：吕晓龙[1] 黄久勤[1] 王红旗[1] Lyu Xiaolong;Huang Jiuqin;Wang Hongqi(Department of Joint Surgery,Shangqiu First People’s Hospital,Shangqiu,Henan 476100,China)

机构地区：[1]商丘市第一人民医院关节外科,河南商丘476100

出　　处：《中华生物医学工程杂志》2021年第3期305-310,共6页Chinese Journal of Biomedical Engineering

基　　金：河南省医学科技攻关计划项目(2018020950)。

摘　　要：探讨CRNDE对白细胞介素1β(IL-1β)诱导的软骨增殖、凋亡和炎性因子表达的影响及可能机制。研究发现,与对照组比较,骨关节炎组患者软骨组织中CRNDE表达升高,而miR-212-5p表达降低。下调CRNDE可靶向负调控miR-212-5p提高IL-1β诱导的软骨细胞增殖,并降低细胞凋亡和炎性因子表达,CRNDE/miR-212-5p轴可能为骨关节炎的治疗提供了新靶点。The purpose of this study is to investigate the effect and possible mechanism of CRNDE on interleukin 1β(IL-1β)-induced proliferation and apoptosis of chondrocytes and secretion of inflammatory factors in osteoarthritis.The study found that,compared with the control group,the CRNDE expression was upregulated,while the miR-212-5p expression was down-regulated,in cartilage tissue of patients with osteoarthritis.In conclusion,down-regulation of CRNDE can target and negatively regulate miR-212-5p,leading to increased IL-1β-induced chondrocyte proliferation,reduced cell apoptosis and expression of inflammatory factors.The CRNDE/miR-212-5p axis may be a new target for treatment of osteoarthritis.

关 键 词：骨关节炎 软骨细胞 炎症 细胞凋亡 

分 类 号：R684.3[医药卫生—骨科学]