噬菌体裂解酶专家共识——齐鲁公共卫生云讲堂  

Expert consensus on bacteriophage endolysin:Qilu Public Health Cloud Forum

作　　者：顾敬敏 杨航[2] 李锦铨 严亚贤[4] 卢雪梅[5] 张炜[6] 胡永飞 王冉[8] 童贻刚 胡福泉 危宏平[2] 刘玉庆[11] 韩文瑜 GU Jingmin;YANG Hang;LI Jinquan;YAN Yaxian;LU Xuemei;ZHANG Wei;HU Yongfei;WANG Ran;TONG Yigang;HU Fuquan;WEI Hongping;LIU Yuqing;HAN Wenyu(College of Veterinary Medicine,Jilin University,Changchun 130062,China;Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China;College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China;School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China;State Key Laboratory of Microbial Technology,Shandong University,Qingdao,Shandong 250100,China;College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China;State Key Laboratory of Animal Nutrition,China Agricultural University,Beijing 100083,China;Institute of Food Safety and Nutrition,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China;Beijing University of Chemical Technology,Beijing 100029,China;Department of Microbiology,Army Medical University,Chongqing 400038,China;Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan 250100,China)

机构地区：[1]吉林大学动物医学学院,吉林长春130062 [2]中国科学院武汉病毒研究所,湖北武汉430071 [3]华中农业大学食品科学技术学院,湖北武汉430070 [4]上海交通大学农业与生物学院,上海200240 [5]山东大学微生物技术国家重点实验室,山东青岛250100 [6]南京农业大学动物医学院,江苏南京210095 [7]中国农业大学动物营养学国家重点实验室,北京100083 [8]江苏省农业科学院农产品质量安全与营养研究所,江苏南京210014 [9]北京化工大学,北京100029 [10]陆军军医大学微生物学教研室,重庆400038 [11]山东省农业科学院畜牧兽医研究所,山东济南250100

出　　处：《中国兽医学报》2021年第8期1451-1457,共7页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(31872505,U19A2038,32072824);吉林省科技发展计划优秀青年人才基金资助项目(20190103106JH);吉林省自然科学基金资助项目(20200201120JC)。

摘　　要：随着抗生素持续、不合理应用乃至滥用,使得细菌对抗生素的耐药性日益严重。特别是抗多黏菌素mcr-1基因以及耐万古霉素"超级细菌"的发现,标志着"后抗生素时代"的来临。为了应对细菌的耐药性、抗生素残留所导致的机体免疫力下降以及环境污染等问题,我国正在全力推进"减抗、限抗、禁抗"战略的实施,这是破解抗生素长期应用引发系列问题的根本之策,是事关畜禽健康养殖、公共卫生安全和人类健康的一件大事。这一战略的实施也对"安全、有效、质量可控,无残留、无污染"的绿色新型替抗剂的研发提出新的需求,亟需在这些方面寻求新的突破口,其中噬菌体裂解酶是一个重要的突破方向。噬菌体裂解酶作为一类新型抗菌蛋白,在应对细菌耐药性方面具有独特优势,在减抗、降抗中具有公共卫生战略价值。为推动噬菌体裂解酶的研究与应用,现汇聚全国十多位从事噬菌体裂解酶研究的专家和相关企业,联合齐鲁公共卫生云讲堂、噬菌体国际研讨会和《中国兽医学报》,专题研讨国内外关于噬菌体裂解酶的基础研究成果和实际应用案例,对噬菌体裂解酶的发展趋势进行分析、研判,形成一系列共识。With the continuous and unreasonable use and abuse of antibiotics,bacterial resistance to antibiotics is becoming increasingly serious.In particular,the discovery of polymyxin resistant mcr-1gene and vancomycin resistant"superbacteria"mark the coming of"post antibiotic era".In order to deal with the drug resistance of bacteria,the decline of immunity and environmental pollution caused by antibiotics and antibiotic residues,China is vigorously promoting the implementation of the strategy of"reducing antibiotics,limiting antibiotics and banning antibiotics",which is the fundamental strategy to solve the series of problems caused by the long-term application of antibiotics,and is a major event related to the healthy breeding of livestock and poultry,public health and human health.The implementation of this strategy also puts forward new demands for the research and development of new substitute agents which are safe,effective,quality controllable,residue free and pollution-free.Bacteriophage endolysin is an important breakthrough direction.As a new class of antibacterial proteins,phage lysin has unique advantages in dealing with antibiotics resistant bacteria,and has a public health strategic value in reducing antibiotics-resistance.In order to promote the research and application of phage lysin.In this research,13experts and related enterprises in China were gathered,in collaboration with Qilu Public Health Cloud Forum,phage international symposium and Chinese Journal of Veterinary Science,to discuss the basic research and practical application of phage lysin,and analyze and judge the development trend of phage lysin.A series of consensus has been formed.

关 键 词：噬菌体 裂解酶 专家共识 齐鲁公共卫生云讲堂 

分 类 号：Q939.48[生物学—微生物学]