[噻唑基-2-^(14)C]-毒氟磷在产蛋鸡体内的分布  

Distribution of [thiazyl-2-C]-Dufulin in Laying Hens

作　　者：骆沛文 张素芬[1] 张晗雪 胡成 余志扬[1] 李秦衎 柴立红[1] 叶庆富[1] LUO Peiwen;ZHANG Sufen;ZHANG Hanxue;HU Cheng;YU Zhiyang;LI Qinkan;CHAI Lihong;YE Qingfu(Institute of Nuclear-Agricultural Science/Key Laboratory for Nuclear Agricultural Sciences of Chinese Ministry of Agriculture and Rural Affairs,PRC and Zhejiang Province,Zhejiang University,Hangzhou,Zhejiang 310058;Shanghai Qizhen Isotech Co.,Ltd.,Shanghai 201403)

机构地区：[1]浙江大学原子核农业科学研究所/农业农村部和浙江省核农学重点实验室,浙江杭州310058 [2]上海启甄环境科技有限公司,上海201403

出　　处：《核农学报》2021年第10期2377-2384,共8页Journal of Nuclear Agricultural Sciences

基　　金：农业行业标准制定和修订项目(181821301092371030)。

摘　　要：为阐明毒氟磷在动物体内的分布代谢特征,并深入认识毒氟磷的安全性和膳食风险,本研究选择白羽产蛋鸡为试验对象,[噻唑基-2-^(14)C]-毒氟磷为同位素示踪剂,研究了毒氟磷在产蛋鸡体内的排泄分布特征。结果表明,毒氟磷在产蛋鸡体内排泄水平高,首次给药24 h后即排泄出当日给药量的82.04%,连续给药7 d后的累计排泄率为82.24%。毒氟磷在组织中的总残留仅占引入量的3.81%,其中胃中残留量占比相对最高,占引入量的2.14%,而肺、肾、脂肪、胰腺中的放射性残留量均不超过引入量的0.01%,膳食评估结果表明在上述内脏组织中的毒氟磷残留无膳食风险。蛋、肌肉、心、脑、脾、卵巢等组织中未检测到放射性残留。本研究为科学评价毒氟磷在家禽中的安全性提供了试验依据。In order to clarify the distribution of Dufulin in animals and evaluating the safety and dietary risk of it, the white laying hens were selected to study excretion and tissue distribution of Dufulin after oral administration, using [thiazyl-2-14C]-Dufulin as a tracer. The results showed as follows: the excretion level of 14C-Dufulin was high. The excretion of 14C-Dufulin within 24 h was 82.04% after 1 d administration, and the cumulative excretion of 14C-Dufulin after 7 d of oral administration was 82.24%. The total radioactive residue of 14C-Dufulin in tissues was 3.81% of applied amount. The percentage in the stomach was 2.14%, which was relatively highest of all the tissues. The 14C concentration was below 0.01% of applied amount in the lung, kidney, fat and pancreas. Dietary exposure assessment showed that there was no dietary risk in the tissues mentioned above. The 14C concentration in eggs, muscle, heart, brain, spleen and ovary was not observed. The distribution of Dufulin in animals is first reported in this paper and it provides experimental data for the safety evaluation of Dufulin in poultry.

关 键 词：毒氟磷 ^(14)C示踪 家禽 分布 排泄 

分 类 号：S859.84[农业科学—临床兽医学]