用胸腺肽α_(1)治疗难治性沙门菌感染对患者T淋巴细胞亚群及嗜酸性粒细胞的影响  

Effect of thymosinα_(1)on T lymphocyte subsets and eosinophils in patients with refra ctory Salmonella infection

作　　者：夏宜兰 耿嘉蔚[1] 张茹薏 梁晓[1] XIA Yilan;GENG Jiawei;ZHANG Ruyi;LIANG Xiao(Department of Infectious Diseases and Hepatopathy,Yunnan First People’s Hospital,Kunming 650100,China)

机构地区：[1]云南省第一人民医院感染疾病及肝病科,云南昆明650100

出　　处：《当代医药论丛》2021年第17期138-139,共2页

摘　　要：目的:分析用胸腺肽α_(1)治疗难治性沙门菌感染对患者T淋巴细胞亚群及嗜酸性粒细胞的影响。方法:选取2014年1月至2015年1月期间在云南省第一人民医院进行住院治疗的23例沙门菌感染患者为研究对象。对23例患者均采用敏感抗生素进行治疗,同时对其进行营养支持等对症治疗。治疗1周后,患者的病情无明显的好转,加用胸腺肽α_(1)对其进行治疗。然后观察23例患者的临床疗效、治疗前后其T淋巴细胞亚群的值及嗜酸性粒细胞计数。结果:23例患者治疗的总有效率为95.6%。单纯使用抗生素治疗前及治疗后,23例患者的CD3^(+)CD45^(+)、CD3^(+)CD4^(+)CD45^(+)、CD4^(+)/CD8^(+)及嗜酸性粒细胞计数相比,P>0.05。加用胸腺肽α_(1)治疗后,23例患者的CD3^(+)CD45^(+)、CD3^(+)CD4^(+)CD45^(+)、CD4^(+)/CD8^(+)及嗜酸性粒细胞计数均高于单用抗生素治疗前后,P<0.05。结论:用胸腺肽α_(1)对难治性沙门菌感染患者进行辅助治疗的效果确切,可提高其机体的免疫功能,维持其外周血中嗜酸性粒细胞的正常水平。Objective:To analyze the effects of thymosinα_(1) on T lymphocyte subsets and eosinophils in patients with refractory salmonella infection.Methods:23 patients with salmonella infection who were hospitalized in The First People’s Hospital of Yunnan Province from January 2014 to January 2015 were selected as the study subjects.All the 23 patients were treated with sensitive antibiotics and received symptomatic treatment such as nutritional support.After 1 week of treatment,the patient showed no significant improvement and was treated with thymosinα_(1).The clinical efficacy,T lymphocyte subsets and eosinophil counts of 23 patients before and after treatment were observed.Results:The total effective rate of 23 patients was 95.6%.CD3^(+)CD45^(+),CD3^(+)CD4^(+)CD45^(+),CD4^(+)/CD8^(+)and eosinophil count in 23 patients before and after treatment with antibiotics alone,P>0.05.The CD3^(+)CD45^(+),CD3^(+)CD4^(+)CD45^(+),CD4^(+)/CD8^(+)and eosinophil counts in 23 patients were higher than those before and after treatment with thymosinα_(1)(P<0.05).Conclusion:Thymosinα_(1) is an effective adjuvant therapy for refractory salmonella infection,which can improve the immune function and maintain the normal level of eosinophil in periphe ral blood.

关 键 词：沙门菌感染 胸腺肽Α1 T淋巴细胞亚群 嗜酸性粒细胞 

分 类 号：R378.2[医药卫生—病原生物学]