妇科千金胶囊与妇科千金片指纹图谱的建立及其比较分析  

Establishment and Comparative Analysis of Fingerprint Chromatogram of Fuke Qianjin Capsule and Tablet

作　　者：粟倩 唐洁[1,2] 张鹏 廖颖妍 谢菁琛 龚云[2,3] 林丽美 SU Qian;TANG Jie;ZHANG Peng;LIAO Yingyan;XIE Jingchen;GONG Yun;LIN Limei(School of Pharmacy,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province,Changsha,Hunan 410208,China;Zhuzhou Qianjin Pharmaceutical Co.,Ltd,Zhuzhou,Hunan 412007,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湘产大宗药材品质评价湖南省重点实验室,湖南长沙410208 [3]株洲千金药业股份有限公司,湖南株洲412007

出　　处：《湖南中医药大学学报》2021年第8期1197-1203,共7页Journal of Hunan University of Chinese Medicine

基　　金：国家中药标准化项目(ZYBZH-C-HUN-21);湖南省重大科技专项(2015SK1001)。

摘　　要：目的建立妇科千金胶囊与妇科千金片的指纹图谱,为两者鉴别与质量评价提供实验依据。方法采用高效液相色谱法对40批妇科千金胶囊与40批妇科千金片进行测定,结合聚类分析、模式识别分析、相似度评价等对其进行比较。结果首次建立了妇科千金胶囊与妇科千金片的指纹图谱,共确定了23个共有峰,指认出了穿心莲内酯和脱水穿心莲内酯两个成分。聚类分析以及模式识别分析均可以明显地将其分为两类,并确定了穿心莲内酯为千金胶囊与妇科千金片的差异性成分。结论该方法重复性好、准确率高,结合各类分析方法可以明确地区分妇科千金胶囊与妇科千金片,可用于对妇科千金胶囊与妇科千金片进行质量控制与评价。Objective To establish the fingerprints of Fuke Qianjin Capsule and Fuke Qianjin Tablet,so as to provide experimental evidence for their identification and quality evaluation.Methods High performance liquid chromatographic method was developed to establish the fingerprint of 40 batches Fuke Qianjin Capsule and 40 batches Fuke Qianjin Tablet and the quality assessment was achieved by cluster analysis,pattern recognition analysis and similarity evaluation.Results It was the first time to establish the HPLC characteristic fingerprints of Fuke Qianjin Capsule and Fuke Qianjin Tablet.There were 23 common peaks in the fingerprints.Two components were identified as andrographolide and dehydrated andrographolide by comparing with reference standards.80 batches of different capsules and tablets were obviously divided into two groups by cluster analysis and pattern recognition analysis and the results of classification were consistent,and andrographolide were determined as the main different chemical components of Fuke Qianjin Capsule and Fuke Qianjin Tablet.Conclusion This method can distinguish the Fuke Qianjin Capsule and Fuke Qianjin Tablet combined with various analysis methods with good repeatability and high accuracy.It can be used to control and evaluate the quality of Fuke Qianjin Capsule and Fuke Qianjin Tablet.

关 键 词：妇科千金胶囊 妇科千金片 指纹图谱 聚类分析 模式判别 

分 类 号：R284.1[医药卫生—中药学]