镍对孕妇妊娠期疾病发病和妊娠结局的影响  

Effect of nickel on occurrence of pregnancy diseases and pregnancy outcome in pregnant women

作　　者：丁爱玲 张婷[2,3] 姚俊秀 郭欣 万慧敏 董旭东[2] DING Ai-Ling;ZHANG Ting;YAO Jun-Xiu(School of Medicine,Kunming University of Science and Technology,the First People’s Hospital of Yunnan,Affiliated Hospital of Kunming University of Science and Technology,Kunming,Yunnan 650500,China)

机构地区：[1]昆明理工大学医学院,云南昆明650500 [2]云南省第一人民医院昆明理工大学附属医院,云南昆明650500 [3]大理大学临床医学院,云南大理761000

出　　处：《中国妇幼保健》2021年第14期3170-3173,共4页Maternal and Child Health Care of China

基　　金：国际科技合作专项重点研发项目(2017IB004);云南省卫生健康委员会高层次卫生健康技术人才培养项目(L-2018006);云南省院士专家工作站(202005AF150033)。

摘　　要：目的分析镍对孕妇妊娠期疾病发病和妊娠结局的影响.方法选取2015年1月-2018年12月在云南省第一人民医院产科住院分娩的71例孕妇,根据孕妇健康状况分为对照组(28例)和疾病组(43例),疾病组孕妇又分为妊娠期糖尿病组(14例,妊娠期糖尿病)、妊娠期高血压疾病组(14例,妊娠期高血压疾病)及妊娠期疾病合并组(15例,妊娠期糖尿病合并妊娠期高血压疾病).收集孕妇基本特征和新生儿出生信息,分娩后立即采集母血、胎盘及脐血样本,检测镍水平.结果对照组母血、胎盘及脐血镍水平分别为(0.08±0.13)μg/L、(0.04±0.06)μg/L及(0.05±0.07)μg/L.疾病组母血、胎盘及脐血镍水平分别为(0.05±0.07)μg/L、(0.06±0.07)μg/L及(0.11±0.20)μg/L.两组母血、胎盘及脐血镍水平比较差异均无统计学意义(t=0.889,P=0.380;t=1.334,P=0.187;t=-1.633,P=0.108).妊娠期糖尿病组母血、胎盘及脐血镍水平分别为(0.03±0.04)μg/L、(0.04±0.07)μg/L及(0.11±0.29)μg/L.妊娠期高血压疾病组母血、胎盘及脐血镍水平分别为(0.06±0.06)μg/L、(0.06±0.05)μg/L及(0.15±0.20)μg/L.妊娠期疾病合并组母血、胎盘及脐血镍水平分别为(0.07±0.09)μg/L、(0.08±0.07)μg/L及(0.06±0.05)μg/L.妊娠期高血压疾病组和对照组脐血镍水平比较差异有统计学意义(t=-2.490,P=0.017).对照组、疾病组母血镍水平/脐血镍水平>1的比例分别为85.7%和60.5%.妊娠期糖尿病组、妊娠期高血压疾病组及妊娠期疾病合并组母血镍水平/脐血镍水平>1的比例分别为71.4%、50.0%及60.0%.结论镍可通过胎盘转移至胎儿,有破坏胎盘组织的潜力.孕妇长期暴露于镍是发生妊娠期疾病和胎儿宫内生长受限的风险因素.Objective To analyze the effect of nickel on occurrence of pregnancy diseases and pregnancy outcome in pregnant women.Methods Seventy-one pregnant women were selected from Department of Obstetrics,the First People’s Hospital of Yunnan from January2015 to December 2018,then they were divided into control group(28 cases)and disease group(43 cases)according to health condition,the pregnant women in disease group were divided into gestational diabetes mellitus(GDM)group(14 cases with GDM),hypertensive disorder complicating pregnancy(HDCP)group(14 cases with HDCP),and combined group(15 cases with GDM and HDCP).The basic characteristics of pregnant women and birth information of neonates were collected,maternal blood,placenta,and umbilical cord blood samples were obtained after delivery,the levels of nickel were detected.Results The levels of nickel in maternal blood,placenta,and umbilical cord blood in control group were(0.08±0.13)μg/L,(0.04±0.06)μg/L,and(0.05±0.07)μg/L,respectively;the levels of nickel in maternal blood,placenta,and umbilical cord blood in disease group were(0.05±0.07)μg/L,(0.06±0.07)μg/L,and(0.11±0.20)μg/L,respectively.There was no statistically significant difference in the levels of nickel in maternal blood,placenta,and umbilical cord blood between the two groups(t=0.889,P=0.380;t=1.334,P=0.187;t=-1.633,P=0.108).The levels of nickel in maternal blood,placenta,and umbilical cord blood in GDM group were(0.03±0.04)μg/L,(0.04±0.07)μg/L,and(0.11±0.29)μg/L,respectively;the levels of nickel in maternal blood,placenta,and umbilical cord blood in HDCP group were(0.06±0.06)μg/L,(0.06±0.05)μg/L,and(0.15±0.20)μg/L,respectively;the levels of nickel in maternal blood,placenta,and umbilical cord blood in combined group were(0.07±0.09)μg/L,(0.08±0.07)μg/L,and(0.06±0.05)μg/L,respectively.There was statistically significant difference in the level of nickel in umbilical cord blood between HDCP group and control group(t=-2.490,P=0.017).The proportions of patients with maternal blood n

关 键 词：镍 妊娠期疾病 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]