IP-10在类风湿关节炎中诊断价值的系统综述和荟萃分析  

Diagnostic value of IP-10 in rheumatoid arthritis:a systematic review and Meta-analysis

作　　者：李清茹 方心宇 夏元睿 过恒升 王军平 毛艳梅[1] 帅宗文[2] 叶冬青[1] LI Qing-ru;FANG Xin-yu;XIA Yuan-rui;GUO Heng-sheng;WANG Jun-ping;MAO Yan-mei;SHUAI Zong-wen;YE Dong-qing(Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei230032,China;Department of Rheumatology and Immunology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学教研室,炎症免疫性疾病安徽省实验室,合肥230032 [2]安徽医科大学第一附属医院风湿免疫科,合肥230032

出　　处：《中华疾病控制杂志》2021年第8期935-942,共8页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81872693)。

摘　　要：目的分析类风湿关节炎(rheumatoid arthritis,RA)中干扰素诱导蛋白10(interferon-inducible protein 10,IP-10)表达水平的变化,评估其在RA中的诊断价值及与疾病活动的相关性。方法通过电子文献检索,在Cochrane图书馆、Scopus和PubMed数据库(截至2020年9月16日)搜索相关的文献,采用诊断准确性研究的质量评估工具2(quality assessment of diagnostic accuracy studies-2,QUADAS-2)对文献进行评价,并进行定量、综合分析。结果最终纳入文献17篇,RA患者IP-10表达水平高于健康对照(healthy control,HC)[标准化均数差(standard mean difference,SMD)=0.93,95%CI:0.51~1.35]。此外,IP-10表达水平在RA与骨关节炎(osteoarthritis,OA)中也存在差异(SMD=3.84,95%CI:0.76~6.92),但在RA和系统性红斑狼疮(systemic lupus erythematosus,SLE)之间差异无统计学意义。IP-10用于RA诊断的合并诊断比值比(diagnostic odds ratio,DOR)为65.70(95%CI:1.52~2844.43),曲线下面积(area under the curve,AUC)为0.8896。结论IP-10表达水平在RA患者与HC和OA患者之间存在差异,可作为潜在的诊断性生物标志物。Objective We aimed to analyze the changes of interferon-inducible protein 10(IP-10)in rheumatoid arthritis(RA)and evaluate the diagnostic value of IP-10 in RA and its correlation with disease activity.Methods We collected articles related to our research topic through an electronic literature search from the Cochrane Library,Scopus,and Pubmed(up to Sep16 th,2020).Quality assessment of diagnostic accuracy studies(QUADAS-2)tool was used to assess the quality of collected articles,and quantitative and comprehensive analysis was conducted.Results 17 studies were finally included in this study.IP-10 level in RA patients was higher than health controls[pooled standard mean difference(SMD)=0.93,95%CI=0.51-1.35].Besides,IP-10 levels in RA patients differed from osteoarthritis(OA)controls,with a pooled SMD and 95%CI being 3.84(0.76-6.92).We found no significant difference in IP-10 levels between RA patients and systemic lupus erythematosus(SLE)controls.The pooled diagnostic odds ratio(DOR)value for IP-10 to diagnose RA was 65.70(1.52-2844.43)and AUC value was 0.8996.Conclusion IP-10 levels differ from RA patients to HC and OA controls,it may be a potential diagnostic biomarker.

关 键 词：干扰素诱导蛋白10 类风湿关节炎 生物标志物 骨关节炎 系统性红斑狼疮 系统综述 荟萃分析 

分 类 号：R181.2[医药卫生—流行病学]