中频穴位电刺激对乳腺癌蒽环类方案化疗患者止吐作用的研究  

Clinical effect of antiemetic treatment with transcutaneous acupoint electrical stimulation on breast cancer patients undergoing anthracycline chemotherapy

作　　者：徐敏[1] 肖寒[1] 奚柯婧 XU Min;XIAO Han;XI Kejing(Department of Integrated Traditional Chinese and Western Medicine Oncology,Affiliated Hospital of Jiangnan Univeritsy,Wuxi,Jiangsu,214062,China)

机构地区：[1]江南大学附属医院中西医结合肿瘤科,江苏无锡214062

出　　处：《当代医学》2021年第25期16-19,共4页Contemporary Medicine

基　　金：无锡市科教强卫人才项目(QNRC060)。

摘　　要：目的探讨中频穴位电刺激联合常规止吐药物缓解乳腺癌蒽环类方案化疗患者呕吐症状的临床效果。方法选取2016年7月至2019年6月就诊于江南大学附属医院中西医结合肿瘤科并使用表柔比星为主方案化疗的57例乳腺癌患者,采用随机数字表法分为对照组(n=28)和治疗组(n=29)。对照组化疗前均使用地塞米松联合阿扎司琼注射液常规止吐治疗,治疗组在对照组治疗基础上使用中频电脉冲治疗仪刺激中脘、内关、足三里穴位。比较两组化疗后24 h评价急性呕吐反应、食欲积分及化疗后120 h评价延迟性呕吐反应、KPS评分、体质量。结果治疗组发生Ⅰ~Ⅳ度急性呕吐反应以及延迟性呕吐反应发生率均明显低于对照组,差异有统计学意义(P<0.05)。化疗后,治疗组KPS评分高于对照组[(73.45±10.46)分vs.(63.21±10.56)分],差异有统计学意义(P<0.05)。治疗组食欲评分低于对照组[(1.38±0.76)分vs.(2.00±1.25)分],差异有统计学意义(P<0.05)。两组体质量比较差异无统计学意义。两组便秘、腹痛腹胀、乏力、头昏头痛、发热等不良反应发生率比较差异无统计学意义。结论中频穴位电刺激联合常规止吐药物对乳腺癌蒽环类方案化疗患者的止吐作用优于单用常规止吐方案,且能改善患者KPS评分以及缓解化疗引起的食欲下降,无明显不良反应发生。Objective To investigate the clinical effect of transcutaneous acupoint electrical stimulation(TEAS)combined with conventional antiemetic drugs in relieving vomiting symptoms of breast cancer patients with anthracycline chemotherapy.Methods From July 2016 to June 2019,57 breast cancer patients who received epirubicin based chemotherapy in the Department of Integrated Chinese and Western Medicine Oncology were selected,and they were randomly divided into control group(n=28)and treatment group(n=29)according to random number table method.The control group was treated with dexamethasone combined with azasetron injection for routine antiemetic therapy before chemotherapy.The treatment group was treated with TEAS,stimulating Zhongwan,Neiguan and Zusanli acupoints on the basis of the control group.Acute vomiting and appetite score at 24 hours after chemotherapy,delayed vomiting reaction,KPS score and body weight were evaluated at 120 hours after chemotherapy were compared between two groups.Results The number of patients with Ⅰ-Ⅳ degree acute vomiting reaction and delayed vomiting reaction in the treatment group were significantly lower than the control group,and the difference was statistically significant(P<0.05).After chemotherapy,KPS score of the treatment group was higher than that of the control group[(73.45±10.46)scores vs.(63.21±10.56)scores],the difference was statistically significant(P<0.05).The appetite score of the treatment group was lower than that of the control group[(1.38±0.76)scores vs.(2.00±1.25)scores],the difference was statistically significant(P<0.05).There was no significant difference in weight loss between the two groups.There was no significant difference in the incidence of constipation,abdominal pain,abdominal distension,fatigue,dizziness,headache,fever and other adverse reactions between the two groups.Conclusion TEAS combined with conventional antiemetic drugs on breast cancer patients undergoing anthracycline chemotherapy is better than that of conventional antiemetic regimen al

关 键 词：中频穴位电刺激 乳腺癌 止吐治疗 

分 类 号：R246.5[医药卫生—针灸推拿学]