Th17/Treg失衡在不明原因复发性自然流产中的作用  

Application of Th17/Treg Immune Imbalance in Unexplained Recurrent Spontaneous Abortion

作　　者：葛育文 张宁[2] GE Yuwen;ZHANG Ning(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;The First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学中医学院,济南250014 [2]山东中医药大学第一临床学院,济南250014

出　　处：《医学综述》2021年第16期3167-3172,共6页Medical Recapitulate

基　　金：山东省中医经典名方协同创新中心开放课题(2019KFY19);山东省中医药科技发展计划项目(2019-0959)。

摘　　要：不明原因复发性自然流产(URSA)的发病原因不明,病理机制目前尚不明确,免疫失衡可能是URSA的病因之一。具有促炎作用的辅助性T细胞17(Th17细胞)和具有抑炎作用的调节性T细胞(Treg细胞)在调节人体免疫稳态中均发挥重要作用,Th17/Treg失衡可导致多种免疫性疾病的发生。Th17/Treg失衡与URSA发病也密切相关,Th17/Treg失衡导致的母胎免疫紊乱可能是URSA发生的重要因素。深入研究Th17/Treg失衡导致URSA发病的具体机制,可以为URSA的早期诊断和治疗提供新的方向。The pathogenesis of unexplained recurrent spontaneous abortion(URSA)is unknown,and the pathological mechanism is still unclear.Immune imbalance may be one of the causes of URSA.Proinflammatory helper T cell 17(Th17)and anti-inflammatory regulatory T cell(Treg)play important roles in the regulation of human immunity,and Th17/Treg imbalance can lead to the occurrence of a variety of immune diseases.Th17/Treg imbalance is closely related to the development of URSA.Maternal and fetal immune disorders resulting from Th17/Treg imbalance may be an important factor in URSA.Further research into the specific mechanism of the Th17/Treg imbalance leading to the onset of URSA is expected to provide a new direction for the early diagnosis and treatment of URSA.

关 键 词：复发性自然流产 辅助性T细胞17 调节性T细胞 免疫失衡 

分 类 号：R714.21[医药卫生—妇产科学]