肠道菌群在2型糖尿病中的作用机制及中药的调控作用  

Research Progress of Mechanism of Action of Intestinal Florain Type 2 Diabetes Mellitus and Regulation Effect of Traditional Chinese Medicine

作　　者：周子钧 纪越 李俊辰 宋逸飞 任桐[1] ZHOU Zijun;JI Yue;LI Junchen;SONG Yifei;REN Tong(Department of Nephrology,the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300382,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300382,China)

机构地区：[1]天津中医药大学第一附属医院肾病科,天津300382 [2]国家中医针灸临床医学研究中心,天津300382

出　　处：《医学综述》2021年第16期3237-3243,共7页Medical Recapitulate

基　　金：国家自然科学基金(81873151);天津市科技计划项目(15ZXLCSY00020)。

摘　　要：2型糖尿病(T2DM)是一种常见的慢性代谢性疾病,严重威胁人类的健康,其发病机制复杂,往往与氧化应激、炎症、胰岛素抵抗等因素密切相关。然而肠道菌群通过短链脂肪酸代谢、胆汁酸代谢、支链氨基酸代谢和脂多糖分泌等途径在T2DM的发生发展中起重要作用。因此,调节肠道菌群,恢复菌群稳态成为治疗T2DM的新方法。而中药在调节肠道菌群、治疗T2DM的过程中有较好的疗效,但具体机制尚未完全明确。因此,深入研究肠道菌群与T2DM的关系,将为进一步明确T2DM的发病机制和诊疗提供新思路。Type 2 diabetes mellitus(T2 DM)is a common chronic metabolic disease,a serious threat to human health,and its pathogenesis is complex,which is often closely related to oxidative stress,inflammation,insulin resistance and other factors.And intestinal flora,through multiple pathways such as short chain fatty acids metabolism,bile acid metabolism,branched chain amino acid metabolism and lipopolysaccharide secretion,plays an important role in the occurrence and development of T2 DM.Therefore,regulating intestinal flora and restoring bacterial homeostasis has become a new method for the treatment of T2 DM.Traditional Chinese medicine has a good effect in the treatment of T2 DM by regulating intestinal flora,although the specific mechanism has not been fully clarified.Therefore,to summarize the relationship between intestinal flora and T2 DM will provide a new idea for further clarifying the pathogenesis,diagnosis and treatment of T2 DM.

关 键 词：2型糖尿病 肠道菌群 发病机制 中药治疗 

分 类 号：R587.1[医药卫生—内分泌]