血管生成素样蛋白3与2型糖尿病及其并发症的相关性研究进展  

Research Progress of Correlation of Angiopoietin-like Protein 3 with Type 2 Diabetes Mellitus and Diabetic Complications

作　　者：张扬 胡雪剑[1] 任建功[1] ZHANG Yang;HU Xuejian;REN Jiangong(Department of Endocrinology and Metabolism,the Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院内分泌与代谢病科,兰州730030

出　　处：《医学综述》2021年第16期3250-3255,共6页Medical Recapitulate

摘　　要：2型糖尿病(T2DM)以糖脂代谢紊乱和胰岛素抵抗为特点,可引起多种慢性并发症。T2DM并发症(眼、肾、心脏、大脑、肢体等病变)的发病机制被认为与血管病变密切相关。血管生成素样蛋白3(ANGPTL3)作为一种肝特异性分泌蛋白,与T2DM及其并发症的发生发展密切相关,其不仅参与调节脂质代谢及胰岛素敏感性,还可通过多种作用机制引起血管病变,进一步明确ANGPTL3与T2DM及其并发症的关系对临床治疗T2DM及其并发症具有重要意义。Type 2 diabetes mellitus(T2 DM)is characterized by disorder of glucose and lipid metabolism and insulin resistance,which can cause a variety of chronic complications.The pathogenesis of T2 DM complications(such as lesions of eye,kidney,heart,brain,limb and so on)is considered to be closely related to vascular diseases.Angiopoietin-like protein 3(ANGPTL3),as a liver specific secretory protein,is closely related to the occurrence and development of T2 DM and its complications,which is not only involved in regulating lipid metabolism and insulin sensitivity,but also can cause vascular lesions through a variety of mechanisms.Further clarification of the correlation between ANGPTL3 and T2 DM and its complications is of great significance for the clinical treatment of T2 DM and its complications.

关 键 词：2型糖尿病 糖尿病并发症 血管生成素样蛋白3 

分 类 号：R587.2[医药卫生—内分泌] R589.2[医药卫生—内科学]