冠状动脉慢血流与超敏CRP及左室舒张功能的相关性研究  

Correlation Study of Slow Coronary Flow,High Sensitive C-reactive protein and Left Ventricular Diastolic Function

作　　者：刘玲玲 韩磊 LIU Lingling;HAN Lei(Dong'e County People's Hospital,Liaocheng 252201,China)

机构地区：[1]东阿县人民医院,山东聊城252201

出　　处：《中国医药指南》2021年第22期11-13,共3页Guide of China Medicine

摘　　要：目的探讨冠状动脉慢血流(SCF)与超敏CRP与左室舒张功能的相关性。方法选择2017年6月至2020年8月我院数据库资料进行分析,调取冠状动脉造影证实存在冠状动脉慢血流,无冠状动脉狭窄,并排除存在高血压、糖尿病、甲状腺疾病、感染性疾病、风湿免疫疾病、肾脏病及瓣膜病、心肌病等其他心脏疾病的患者32例作为慢血流组。选取同期在我院住院体检冠状动脉造影阴性的健康者30名作为健康对照组。对入试者入院当天行超敏CRP及超声心动图检查。观察冠状动脉慢血流组与健康对照组的超声相关参数:E/A、E'、E/E'左房前后径及超敏CRP的对比情况以及观察冠状动脉慢血流组E/A、E'、E/E'左房前后径、超敏CRP各指标的相关性。结果冠状动脉慢血流组与健康对照组组间年龄、E/A及hs-CRP的差异有显著统计学意义,与健康对照组相比,冠状动脉慢血流组E/A比值相对较低,年龄、hs-CRP显著升高。Pearson相关分析结果显示:冠状动脉慢血流组E/A与E'呈现中度正相关,E'与hs-CRP呈中度负相关,E/E'与LA前后径呈高度正相关。结论冠状动脉慢血流患者hs-CRP较健康人群明显升高,左室舒张功能相关参数E/A相对减低,且E/A与E'、E'与hs-CRP、E/E'与LA前后径存在相关性。超敏CRP及E/A比值可作为评估冠状动脉慢血流患者严重程度的相关指标。Objective To explore the correlation between coronary slow blood flow(SCF),high-sensitivity CRP and left ventricular diastolic function.Methods Select the database data of our hospital from June 2017 to August 2020 for analysis,obtain coronary angiography to confirm the presence of slow coronary blood flow,no coronary artery stenosis,and exclude the presence of hypertension,diabetes,thyroid disease,infectious diseases,Thirty-two patients with rheumatic immune disease,kidney disease,valvular disease,cardiomyopathy and other heart diseases were included in the slow blood flow group.Thirty healthy people who were hospitalized in our hospital with negative coronary angiography during the same period were recruited as healthy controls.On the day of admission,the patients should complete the hypersensitivity CRP and echocardiographic examinations.Observe the ultrasoundrelated parameters of the coronary slow blood flow group and the healthy control group:E/A,E',E/E'left atrium anteroposterior diameter and hypersensitive CRP comparison,and observe the coronary slow blood flow group E/A,Correlation of E',E/E'left atrium anteroposterior diameter and hypersensitivity CRP indicators.Results The difference in age,E/A and hs-CRP between the slow coronary blood flow group and the healthy control group was statistically significant.Compared with heulthy control group,the E/A ratio of the slow coronary blood flow group was relatively low,and the hs-CRP was significantly increased.Pearson correlation analysis results show:in the coronary artery slow blood flow group,E/A and E'were moderately positively correlated,E'and hs-CRP were moderately negatively correlated,and E/E'was highly positively correlated with the anterior and posterior diameter of LA.Conclusion The hs-CRP of patients with slow coronary blood flow was significantly higher than that of healthy people,and the related parameters of left ventricular diastolic function E/A were relatively lower,and E/A and E',E'and hs-CRP,E/E'and LA before and after there is a correlatio

关 键 词：冠状动脉慢血流 超敏C反应蛋白 左室舒张功能 

分 类 号：R541.4[医药卫生—心血管疾病]