灵芝三萜类成分药理活性研究进展  

Research progress on pharmacological activities of triterpenes from Ganoderma lucidum

作　　者：罗云[1] 陈霖 张雪涟 兰进[1] 魏菲[1] 孙晓波[1] LUO Yun;CHEN Lin;ZHANG Xue-lian;LAN Jin;WEI Fei;SUN Xiao-bo(Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China)

机构地区：[1]中国医学科学院药用植物研究所,北京100193

出　　处：《中国药理学通报》2021年第9期1185-1188,共4页Chinese Pharmacological Bulletin

基　　金：国家重点研发计划资助项目(No 2019YFC1710504)。

摘　　要：灵芝作为我国药食两用传统名贵中药,化学成分主要有三萜类、多糖、有机酸、生物碱、氨基酸等,其中灵芝三萜类化合物主要包括灵芝酸和灵芝醇。该文总结了近几年灵芝三萜在抗肿瘤、抗炎、保肝、保肾、调节免疫、降血脂、降血糖、抗菌等方面药理活性研究,以期为高品质灵芝核心功效评价提供参考依据;也为灵芝在保健食品和临床医学中的应用提供科学依据。Ganoderma lucidum is a valuable traditional Chinese medicine with dual use of medicine and food in China.Its chemical components mainly include triterpenoids,polysaccharides,organic acids,alkaloids,amino acids and so forth.The triterpenoids mainly include ganoderma acid and ganoderma alcohol.This paper has summarized the pharmacological activities of Ganoderma lucidum triterpenes in anti-tumor,anti-inflammatory,liver and kidney protection,immune regulation,blood lipid and blood glucose lowering,and antimicrobial activities in recent years,in order to provide reference basis for the core efficacy evaluation of high-quality Ganoderma lucidum.It also provides scientific evidence for the application of Ganoderma lucidum in health food and clinical medicine.

关 键 词：灵芝三萜 灵芝酸 灵芝醇 药理活性 高品质灵芝 

分 类 号：R282.71[医药卫生—中药学] R284.1[医药卫生—中医学]