类器官培养在癌症中的应用及展望  

Application and prospect of organoid culture in cancer

作　　者：谢雨欣 许峰晟 王彤 杨春宇 周雪冰 任香善 XIE Yu-xin;XU Feng-sheng;WANG Tong;YANG Chun-Yu;ZHOU Xue-bing;REN Xiang-shan(College of Medicine,Yanbian University,Yanji Jilin 133002,China;Cancer Research Center of Yanbian University,Yanji Jilin 133002,China;State Key Laboratory of Civil Affairs/Key Laboratory of Science and Technology Dept of Jilin Province,Yanji Jilin 133002,China)

机构地区：[1]延边大学医学院,吉林延吉133002 [2]延边大学肿瘤研究中心,吉林延吉133002 [3]延边大学国家民委重点实验室/吉林省科技厅重点实验室,吉林延吉133002

出　　处：《中国药理学通报》2021年第9期1197-1201,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 31460303,81660609);吉林省科技厅项目(No 20180101007);吉林省教育厅项目(No JJKH20191116KJ)。

摘　　要：目前,针对癌症研究的常用传统模型包括2D细胞模型、人源肿瘤异种移植模型和动物模型等。随着研究的深入,传统的肿瘤模型已无法满足科研人员的研究需求,建立更接近于肿瘤组织特点的临床前模型是亟待解决的问题。类器官模型来源于肿瘤患者的手术标本,能完整的保存肿瘤的组织学及基因组特性,可用于肿瘤发病机制的研究、药物筛查、患者个性化治疗等,相比传统模型具有建模时间短、经济实惠及更接近原肿瘤特点等优势。该文主要针对类器官技术在肿瘤中的研究现状,类器官模型在治疗方面的应用,及类器官模型相比传统模型的优势等方面进行阐述,以期为后续研究提供参考。At present,the traditional models for cancer research include the 2D cell model,human tumor xenograft model and animal model.With the deepening of research,the traditional tumor model is unable to meet the needs of researchers.Organoid model is derived from the surgical specimens of tumor patients,which can completely preserve the histological and genomic characteristics of tumor.It can be used in the research of tumor pathogenesis,drug screening,personalized treatment of patients,etc.Compared with traditional model,it has the advantages of short modeling time,economic benefits and closerness to the characteristics of the original tumor.This paper mainly focuses on the research status of organoid technology in tumor,the application of organoid model in treatment,and the advantages of organoid model compared with traditional model,so as to provide reference for the follow-up research.

关 键 词：类器官 癌症 研究现状 发生机制 精准治疗 新药开发 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R363-332[医药卫生—基础医学]