2型糖尿病突发耳聋应用高压氧辅助治疗的临床疗效研究  

Study on the Clinical Efficacy of Hyperbaric Oxygen Adjuvant Therapy for Sudden Deafness in Type 2 Diabetes

作　　者：朱宇 侯春婷 ZHU Yu;HOU Chunting(Department of Otorhinolaryngology,No.964 Hospital,Changchun,Jilin Province,130062 China)

机构地区：[1]第964医院耳鼻咽喉科,吉林长春130062

出　　处：《糖尿病新世界》2021年第12期179-182,共4页Diabetes New World Magazine

摘　　要：目的探讨2型糖尿病突发耳聋应用高压氧辅助治疗的临床疗效。方法抽取该院2017年9月—2018年9月收治的2型糖尿病突发耳聋患者88例,抓阄法分设对照组(44例,糖皮质激素+常规治疗)和研究组(糖皮质激素+常规治疗+高压氧辅助治疗)。治疗后对比两组血清学应激因子及炎性因子、纯音阈水平、血糖水平、并发症及不良反应发生率。结果治疗3个疗程后,研究组纯音听阈显著低于对照组同期及同组治疗前,差异有统计学意义(P<0.05);研究组3个疗程每一疗程治疗后血糖水平显著低于对照组同期,各疗程血糖均呈持续性下降,差异有统计学意义(P<0.05);研究组治疗3个疗程后,C-反应蛋白水平显著低于对照组同期及同组治疗前,NO及NOS水平显著高于对照组同期及同组治疗前,差异有统计学意义(P<0.05);治疗后两组不良反应及并发症发生率对比,差异无统计学意义(P>0.05)。结论于2型糖尿病突发耳聋患者应用高压氧辅助治疗,可减低患者血清学应激因子及炎症因子水平,安全性及降糖效能确切。Objective To explore the clinical efficacy of hyperbaric oxygen adjuvant therapy for sudden deafness in type 2 diabetes.Methods A sample of 88 patients with sudden deafness of type 2 diabetes who were admitted to this hospital from September 2017 to September 2018 were divided into a control group(44 cases,glucocorticoid+conventional treatment)and a study group(glucocorticoid+conventional treatment+Adjuvant therapy with hyperbaric oxygen).After treatment,compared the two groups of serum stress factors and inflammatory factors,pure tone threshold levels,blood glucose levels,complications and adverse reactions.Results After 3 courses of treatment,the pure tone hearing threshold of the study group was significantly lower than that of the control group and before the treatment.The difference was statistically significant(P<0.05);the blood glucose level of the study group after 3 courses of treatment was significantly lower than that of the control group.During the same period,the blood glucose of each course of treatment showed a continuous decrease,the difference was statistically significant(P<0.05).After 3 courses of treatment in the study group,the level of C-reactive protein was significantly lower than that of the control group during the same period and before the treatment of this group,and the levels of NO and NOS were significantly higher than those of the control group during the same period and before the treatment of this group.The difference was statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions and complications between the two groups after treatment(P>0.05).Conclusion The application of hyperbaric oxygen adjuvant therapy to patients with sudden deafness in type 2 diabetes can reduce the levels of serum stress factors and inflammatory factors,and the safety and hypoglycemic efficacy are accurate.

关 键 词：2型糖尿病 突发耳聋 高压氧辅助 应激水平 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]