早期糖尿病肾病患者血细胞形态变化分析  

Analysis of Blood Cell Morphological Changes in Patients with Early Diabetic Nephropathy

作　　者：谭柏松[1] 丘仲柳[1] 陈世豪[1] 林耀威 TAN Baisong;QIU Zhongliu;CHEN Shihao;LIN Yaowei(Department of Laboratory Medicine,People's Hospital of Xinhui District,Jiangmen,Guangdong Province,529100 China)

机构地区：[1]江门市新会区人民医院检验科,广东江门529100

出　　处：《糖尿病新世界》2021年第11期182-185,共4页Diabetes New World Magazine

摘　　要：目的探讨并分析早期糖尿病肾病患者血细胞形态的变化情况。方法选取2018年1月—2019年12月在该院确诊为早期糖尿病肾病的533例患者作为观察组,同期选取500名在该院体检的健康人作为对照组,对其临床资料进行回顾性的分析,两组均进行血糖、血压、尿白蛋白排泄率、血细胞形态、血生化指标、肾小球形态变化等检测,对两组各项指标进行统计,并采用统计学软件进行分析比较。结果与对照组相比较,观察组患者血压、血糖、尿白蛋白排泄率、血红细胞压积等指标均较高,平均红细胞血红蛋白浓度较低,差异有统计学意义(P<0.05);在肾小球结构形态方面,与对照组相比较,观察组单个血管腔细胞个数更多、肾小球直径更大、肾小球基底膜厚度较厚、肾小球系膜增生指数较大,差异有统计学意义(P<0.05)。结论对早期糖尿病肾病患者进行血细胞形态变化的分析,通过对血压、血糖、尿白蛋白排泄率、血红细胞压积及血红蛋白浓度指标水平进行观察,同时结合肾小球形态变化特征,能够对早期糖尿病肾病提供诊断的依据,提高早期糖尿病肾病诊断的准确性,为后续尽早治疗提供可靠依据。Objective To explore and analyze the changes of blood cell morphology in patients with early diabetic nephropathy.Methods Selected 533 patients diagnosed with early diabetic nephropathy in the hospital from January 2018 to December 2019 as the observation group,and selected 500 healthy people who were in the hospital for physical examination at the same time as the control group,and retrospectively analyzed their clinical data,both groups were tested for blood glucose,blood pressure,urine albumin excretion rate,blood cell morphology,blood biochemical indicators,glomerular morphological changes,etc.The indicators of the two groups were counted,and statistical software was used for analysis and comparison.Results Compared with the control group,the observation group had higher blood pressure,blood glucose,urinary albumin excretion rate,hematocrit and other indicators,but the mean corpuscular hemoglobin concentration was lower,the difference was statistically significant(P<0.05).In terms of the structure and morphology of the glomerulus,compared with the control group,the observation group had more single vascular cavity cells,larger glomerular diameter,thicker glomerular basement membrane,and larger mesangial proliferation index.The difference was statistical significance(P<0.05).Conclusion The analysis of blood cell morphology changes in patients with early diabetic nephropathy,through observation of blood pressure,blood glucose,urine albumin excretion rate,hematocrit and hemoglobin concentration index levels,combined with the characteristics of glomerular morphology,can provide a basis for diagnosis of diabetic nephropathy,improve the accuracy of early diagnosis of diabetic nephropathy,and provide a reliable basis for early follow-up treatment.

关 键 词：早期糖尿病肾病 血细胞 形态变化 生化指标 肾小球结构 

分 类 号：R587[医药卫生—内分泌]